AC   MF_01672;
DC   Protein; auto
TR   HAMAP; MF_01672; -; 1; level=0
XX
Names: IolE
XX
ID   IOLE
DE   RecName: Full=Inosose dehydratase;
DE            EC=4.2.1.44;
DE   AltName: Full=2-keto-myo-inositol dehydratase;
DE            Short=2KMI dehydratase;
GN   Name=iolE;
XX
CC   -!- FUNCTION: Catalyzes the dehydration of inosose (2-keto-myo-inositol,
CC       2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-
CC       trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione +
CC         H2O; Xref=Rhea:RHEA:14065, ChEBI:CHEBI:15377, ChEBI:CHEBI:17811,
CC         ChEBI:CHEBI:28446; EC=4.2.1.44;
CC   -!- COFACTOR:
CC       Name=glutathione; Xref=ChEBI:CHEBI:57925;
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
case <OC:Bacillota>
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC       acetyl-CoA from myo-inositol: step 2/7.
end case
CC   -!- SIMILARITY: Belongs to the IolE/MocC family.
XX
DR   Pfam; PF01261; AP_endonuc_2; 1; trigger=no
XX
KW   Cobalt
KW   Lyase
KW   Manganese
XX
GO   GO:0030145; F:manganese ion binding
GO   GO:0050114; F:myo-inosose-2 dehydratase activity
GO   GO:0019310; P:inositol catabolic process
XX
Size: 297-308;
Related: None;
Template: P42416;
Scope:
 Bacteria; Bacillota
 Bacteria; Gammaproteobacteria
 Bacteria; Mycoplasmatota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACCZ
Plasmid: in BACCZ
Comments: None
XX
# Revision 1.13 2023/02/17
//