HAMAP logo

HAMAP rule MF_01695

Send feedback

General rule information [?]

Accession MF_01695
Dates 20-SEP-2010 (Created)
1-JUN-2023 (Last updated, Version 13)
Name MshA
Scope(s) Bacteria
Actinomycetota
Template(s) Q8NTA6 (MSHA_CORGL); P9WMY7 (MSHA_MYCTU); A0QQZ8 (MSHA_MYCS2); [ Recover all ]
Triggered by HAMAP; MF_01695 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MSHA
Protein name RecName: Full=D-inositol-3-phosphate glycosyltransferase;
                 EC=2.4.1.250;
AltName: Full=N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase;
                 Short=GlcNAc-Ins-P N-acetylglucosaminyltransferase;
Gene name Name=mshA;

Comments [?]

FUNCTIONCatalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
CATALYTIC ACTIVITY Reaction=1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3- phosphate + H(+) + UDP; Xref=Rhea:RHEA:26188, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:58401, ChEBI:CHEBI:58892; EC=2.4.1.250;
SUBUNITHomodimer.
SIMILARITYBelongs to the glycosyltransferase group 1 family. MshA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0008375; Molecular function:acetylglucosaminyltransferase activity
GO:0010125; Biological process:mycothiol biosynthetic process

Cross-references [?]

Pfam PF08323; Glyco_transf_5; 1;
Pfam PF00534; Glycos_transf_1; 1;
NCBIfam TIGR03449; Mycothiol_MshA; 1;

Features [?]

From: MSHA_CORGL (Q8NTA6)
Key From To Description Tag Condition FTGroup
BINDING 15 16 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
/ligand_id="ChEBI:CHEBI:57705"
Q-P
BINDING 20 25 /ligand="1D-myo-inositol 3-phosphate"
/ligand_id="ChEBI:CHEBI:58401"
D-x-G-x-[ML]-N
BINDING 303 303 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
[YFIM]
BINDING 304 304 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
[RHQ]
BINDING 306 306 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
[ACSV]
BINDING 330 330 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
T
BINDING 9 9 /ligand="1D-myo-inositol 3-phosphate"
/ligand_id="ChEBI:CHEBI:58401"
H
BINDING 23 23 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
/ligand_id="ChEBI:CHEBI:57705"
G
BINDING 78 78 /ligand="1D-myo-inositol 3-phosphate"
/ligand_id="ChEBI:CHEBI:58401"
[KR]
BINDING 110 110 /ligand="1D-myo-inositol 3-phosphate"
/ligand_id="ChEBI:CHEBI:58401"
[YH]
BINDING 134 134 /ligand="1D-myo-inositol 3-phosphate"
/ligand_id="ChEBI:CHEBI:58401"
[TS]
BINDING 154 154 /ligand="1D-myo-inositol 3-phosphate"
/ligand_id="ChEBI:CHEBI:58401"
[RQ]
BINDING 231 231 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
/ligand_id="ChEBI:CHEBI:57705"
R
BINDING 236 236 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
/ligand_id="ChEBI:CHEBI:57705"
K
BINDING 294 294 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
/ligand_id="ChEBI:CHEBI:57705"
[RMQV]
BINDING 316 316 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
/ligand_id="ChEBI:CHEBI:57705"
E
BINDING 324 324 /ligand="UDP-N-acetyl-alpha-D-glucosamine"
/ligand_id="ChEBI:CHEBI:57705"
E

Additional information [?]

Size range 407-496 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)