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HAMAP rule MF_01921

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General rule information [?]

Accession MF_01921
Dates 13-MAY-2014 (Created)
1-JUN-2023 (Last updated, Version 9)
Name TYW1_archaea
Scope(s) Archaea
Template(s) Q57705 (TYW1_METJA); Q9V1F9 (TYW1_PYRAB); O59412 (TYW1_PYRHO); [ Recover all ]
Triggered by HAMAP; MF_01921 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TYW1
Protein name RecName: Full=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase;
                 EC=4.1.3.44;
AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw1;
Gene name Name=taw1;

Comments [?]

FUNCTIONComponent of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
CATALYTIC ACTIVITY Reaction=N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl- L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine; Xref=Rhea:RHEA:36347, Rhea:RHEA- COMP:10164, Rhea:RHEA-COMP:10165, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:16526, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315, ChEBI:CHEBI:73542; EC=4.1.3.44;
case <FTGroup:1>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
SUBUNITMonomer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the TYW1 family.

Keywords [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
end case
GO:0016833; Molecular function:oxo-acid-lyase activity
GO:0008033; Biological process:tRNA processing
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
Pfam PF08608; Wyosine_form; 1;
NCBIfam TIGR03972; rSAM_TYW1; 1;

Features [?]

From: TYW1_METJA (Q57705)
Key From To Description Tag Condition FTGroup
BINDING 26 26 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"
C 1
BINDING 39 39 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"
C 1
BINDING 52 52 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"
C 1
BINDING 62 62 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
/ligand_note="4Fe-4S-S-AdoMet"
C 1
BINDING 66 66 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
/ligand_note="4Fe-4S-S-AdoMet"
C 1
BINDING 69 69 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
/ligand_note="4Fe-4S-S-AdoMet"
C 1

Additional information [?]

Size range 288-386 amino acids
Related rules None
Fusion Nter: None Cter: None



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