HAMAP rule MF_01923
General rule information
[?]
| Accession | MF_01923 |
| Dates | 23-MAY-2014 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | Me_Asp_mutase_E |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P80077 (GLME_CLOCO); Q05509 (GLME_CLOTT); [ Recover all ] |
| Triggered by |
HAMAP; MF_01923 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | GLME |
| Protein name | RecName: Full=Glutamate mutase epsilon subunit; EC=5.4.99.1; AltName: Full=Glutamate mutase E chain; AltName: Full=Glutamate mutase large subunit; AltName: Full=Methylaspartate mutase; |
| Gene name | Name=glmE; |
Comments
[?]
| FUNCTION | Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). |
| CATALYTIC ACTIVITY | Reaction=(2S,3S)-3-methyl-L-aspartate = L-glutamate; Xref=Rhea:RHEA:12857, ChEBI:CHEBI:29985, ChEBI:CHEBI:58724; EC=5.4.99.1; |
| COFACTOR | Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408; |
| PATHWAY | Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4. |
| SUBUNIT | Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer. |
| SIMILARITY | Belongs to the methylaspartate mutase GlmE subunit family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0050097; Molecular function:methylaspartate mutase activity |
| GO:0019670; Biological process:anaerobic glutamate catabolic process |
Cross-references
[?]
| Pfam | PF06368; Met_asp_mut_E; 1; |
| NCBIfam | TIGR01503; MthylAspMut_E; 1; |
| PIRSF | PIRSF001495; Met_asp_mut_epsi; 1; |
Features
[?]
| From: GLME_CLOCO (P80077) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 149 | 150 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985" |
[RK]-H | ||||||||
| BINDING | 66 | 66 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985" |
R | ||||||||
| BINDING | 68 | 68 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
G | ||||||||
| BINDING | 100 | 100 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985" |
R | ||||||||
| BINDING | 123 | 123 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
N | ||||||||
| BINDING | 171 | 171 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985" |
[ED] | ||||||||
| BINDING | 177 | 177 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985" |
Y | ||||||||
| BINDING | 180 | 180 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
P | ||||||||
| BINDING | 181 | 181 | /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985" |
Y | ||||||||
| BINDING | 297 | 297 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
F | ||||||||
| BINDING | 326 | 326 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
K | ||||||||
| BINDING | 330 | 330 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
E | ||||||||
| BINDING | 334 | 334 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
I | ||||||||
Additional information
[?]
| Size range | 440-520 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |