HAMAP rule MF_01937
General rule information
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Accession | MF_01937 |
Dates | 28-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 6) |
Name | MenA_1 |
Scope(s) |
Bacteria Archaea |
Template(s) | P32166 (MENA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01937 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MENA |
Protein name | RecName: Full=1,4-dihydroxy-2-naphthoate octaprenyltransferase; Short=DHNA-octaprenyltransferase; EC=2.5.1.74; |
Gene name | Name=menA; |
Comments
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FUNCTION | Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). |
CATALYTIC ACTIVITY | Reaction=1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate; Xref=Rhea:RHEA:26478, Rhea:RHEA-COMP:9563, Rhea:RHEA-COMP:9564, ChEBI:CHEBI:11173, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33019, ChEBI:CHEBI:55437, ChEBI:CHEBI:58914; EC=2.5.1.74; |
PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2. |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the MenA family. Type 1 subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Cell membrane | |
Membrane | |
Menaquinone biosynthesis | |
Transferase | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
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GO:0046428; Molecular function:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity |
GO:0009234; Biological process:menaquinone biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF01040; UbiA; 1; |
NCBIfam | TIGR00751; menA; 1; |
PIRSF | PIRSF005355; UBIAD1; 1; |
General | Transmembrane; -; 6-9; |
Features
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Additional information
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Size range | 275-360 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |