HAMAP rule MF_01945

General rule information [?]

Accession	MF_01945
Dates	17-DEC-2014 (Created) 29-SEP-2022 (Last updated, Version 7)
Name	Lipid_A_LpxT
Scope(s)	Bacteria Enterobacterales
Template(s)	P76445 (LPXT_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01945 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LPXT
Protein name	RecName: Full=Lipid A 1-diphosphate synthase; EC=2.7.4.29; AltName: Full=Kdo(2)-lipid A phosphotransferase; AltName: Full=Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase;
Gene name	Name=lpxT;

Comments [?]

FUNCTION	Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P).
case <OC:Escherichia>
CATALYTIC ACTIVITY	Reaction=alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di- trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1- diphosphate + di-trans,octa-cis-undecaprenyl phosphate; Xref=Rhea:RHEA:45468, ChEBI:CHEBI:58405, ChEBI:CHEBI:58540, ChEBI:CHEBI:60392, ChEBI:CHEBI:85271; EC=2.7.4.29;
else
CATALYTIC ACTIVITY	Reaction=an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa- cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo- (2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate; Xref=Rhea:RHEA:74291, ChEBI:CHEBI:58405, ChEBI:CHEBI:60392, ChEBI:CHEBI:176431, ChEBI:CHEBI:193150; EC=2.7.4.29;
end case
PATHWAY	Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein. Note=Transferase activity takes place on the periplamic side of the inner membrane.
SIMILARITY	Belongs to the LpxT phosphotransferase family.

Keywords [?]

Gene Ontology [?]

GO:0016776; Molecular function:phosphotransferase activity, phosphate group as acceptor

GO:0009245; Biological process:lipid A biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF01569; PAP2; 1;
General	Transmembrane; -; 5-6;

Features [?]

Additional information [?]