AC MF_01966; DC Protein; auto c? or TR HAMAP; MF_01966; -; 1; level=0 XX Names: NADHX_epimerase XX ID NNRE DE RecName: Full=NAD(P)H-hydrate epimerase; DE EC=5.1.99.6; DE AltName: Full=NAD(P)HX epimerase; GN Name=nnrE; XX CC -!- FUNCTION: Catalyzes the epimerization of the S- and R-forms of CC NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or CC heat-dependent hydration. This is a prerequisite for the S-specific CC NAD(P)H-hydrate dehydratase to allow the repair of both epimers of CC NAD(P)HX. CC -!- CATALYTIC ACTIVITY: CC Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215, CC ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=5.1.99.6; CC -!- CATALYTIC ACTIVITY: CC Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227, CC ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=5.1.99.6; CC -!- COFACTOR: CC Name=K(+); Xref=ChEBI:CHEBI:29103; CC Note=Binds 1 potassium ion per subunit.; CC -!- SIMILARITY: Belongs to the NnrE/AIBP family. XX DR PROSITE; PS51385; YJEF_N; 1; trigger=yes DR Pfam; PF03853; YjeF_N; 1; trigger=no DR NCBIfam; TIGR00197; YjeF_nterm; 1; trigger=no XX KW Isomerase KW Metal-binding KW NAD KW NADP KW Nucleotide-binding KW Potassium XX GO GO:0052856; F:NADHX epimerase activity XX FT From: NNR_THEMA (Q9X024) FT BINDING 51..55 FT /ligand="(6S)-NADPHX" FT /ligand_id="ChEBI:CHEBI:64076" FT Condition: x-N-G-x(2) FT BINDING 118..124 FT /ligand="(6S)-NADPHX" FT /ligand_id="ChEBI:CHEBI:64076" FT BINDING 52 FT /ligand="K(+)" FT /ligand_id="ChEBI:CHEBI:29103" FT Condition: N FT BINDING 114 FT /ligand="K(+)" FT /ligand_id="ChEBI:CHEBI:29103" FT Condition: D FT BINDING 150 FT /ligand="K(+)" FT /ligand_id="ChEBI:CHEBI:29103" FT Condition: [ST] FT BINDING 129 FT /ligand="(6S)-NADPHX" FT /ligand_id="ChEBI:CHEBI:64076" FT Optional; Condition: Y FT BINDING 147 FT /ligand="(6S)-NADPHX" FT /ligand_id="ChEBI:CHEBI:64076" FT Condition: [DE] XX Size: 204-288; Related: None; Template: Q9X024; P31806; Scope: Bacteria Archaea Fusion: Nter: None Cter: MF_01965 (nnrD) Duplicate: None Plasmid: None Comments: None XX # Revision 1.14 2023/06/01 //