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| HAMAP annotation rule MF_02113 |
| Accession | MF_02113 |
| Dates | 2-JUL-2010 (Created) 9-NOV-2012 (Last updated, Version 5) |
| Name | Proteasome_B |
| Scope | Archaea Bacteria; Actinobacteria |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
| Identifier |
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case <OC:Bacteria>
| Protein name |
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| Gene name |
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end case
case <OC:Archaea>
| Protein name |
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| Gene name |
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end case
| FUNCTION | Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity). |
| CATALYTIC ACTIVITY | Cleavage of peptide bonds with very broad specificity. |
case <OC:Bacteria>
| ENZYME REGULATION | The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity (By similarity). |
| PATHWAY | Protein degradation; proteasomal pup-dependent pathway. |
| SUBUNIT | The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC (By similarity). |
end case
case <OC:Archaea>
| ENZYME REGULATION | The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity (By similarity). |
| SUBUNIT | The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN (By similarity). |
end case
| SUBCELLULAR LOCATION | Cytoplasm (By similarity). |
| SIMILARITY | Belongs to the peptidase T1B family. |
GO:0004298; Molecular function: threonine-type endopeptidase activity.
GO:0010498; Biological process: proteasomal protein catabolic process.
GO:0010498; Biological process: proteasomal protein catabolic process.
case <OC:Bacteria>
GO:0019941; Biological process: modification-dependent protein catabolic process.
end case
GO:0005737; Cellular component: cytoplasm.
GO:0019774; Cellular component: proteasome core complex, beta-subunit complex.
GO:0019774; Cellular component: proteasome core complex, beta-subunit complex.
| PROSITE | PS00854; PROTEASOME_B_1; 1; |
| PS51476; PROTEASOME_B_2; 1; | |
| Pfam | PF00227; Proteasome; 1; |
| PRINTS | PR00141; PROTEASOME; 1; |
| TIGRFAMs | TIGR03634; Arc_protsome_B; 1; |
| TIGR03690; 20S_bact_beta; 1; |
case <OC:Archaea>
| From: PSB_THEAC (P28061) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| PROPEP | Nter | 8 | Removed in mature form; by autocatalysis (By similarity) | |||||||||
| CHAIN | 9 | Cter | Proteasome subunit beta | |||||||||
| ACT_SITE | 9 | 9 | Nucleophile (By similarity) | T | ||||||||
end case
case <OC:Bacteria>
| From: PSB_MYCTU (O33245) | ||||||||||||
| PROPEP | Nter | 57 | Removed in mature form; by autocatalysis (By similarity) | |||||||||
| CHAIN | 58 | Cter | Proteasome subunit beta | |||||||||
| ACT_SITE | 58 | 58 | Nucleophile (By similarity) | T | ||||||||
end case
case <OC:Bacteria>
| Size range: | 269-306 amino acids |
end case
case <OC:Archaea>
| Size range: | 193-243 amino acids |
end case
| Related Rules: | None |
| Templates: | P28061 (PSB_THEAC); O33245 (PSB_MYCTU); Q9P996 (PSB_ARCFU); Q58634 (PSB_METJA); D4GYZ1 (PSB_HALVD); Q53079 (PSB1_RHOER); Q53083 (PSB2_RHOER): [Recover all] |
| Fusion: | None |
| Comments: | Subunit alpha of the proteasome core is in MF_00289. |