AC   MF_02114;
DC   Protein; auto
TR   HAMAP; MF_02114; -; 1; level=0
XX
Names: CofC
XX
case <OC:Archaea>
ID   COFC
DE   RecName: Full=2-phospho-L-lactate  guanylyltransferase;
DE            Short=LP guanylyltransferase;
DE            EC=2.7.7.68;
GN   Name=cofC;
else case <OC:Actinomycetota>
ID   FBID
DE   RecName: Full=Phosphoenolpyruvate guanylyltransferase;
DE            Short=PEP guanylyltransferase;
DE            EC=2.7.7.105;
GN   Name=fbiD;
else case <OC:Pseudomonadota>
ID   FBID
DE   RecName: Full=3-phospho-D-glycerate guanylyltransferase;
DE            Short=3PG guanylyltransferase;
DE            EC=2.7.7.106;
GN   Name=fbiD;
else
ID   FBID
DE   RecName: Full=Phosphoenolpyruvate guanylyltransferase;
DE            Short=PEP guanylyltransferase;
DE            EC=2.7.7.105;
GN   Name=fbiD;
end case
XX
case <OC:Archaea>
CC   -!- FUNCTION: Guanylyltransferase that catalyzes the activation of (2S)-2-
CC       phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the
CC       condensation of 2-PL with GTP. It is involved in the biosynthesis of
CC       coenzyme F420, a hydride carrier cofactor.
else case <OC:Actinomycetota>
CC   -!- FUNCTION: Guanylyltransferase that catalyzes the activation of
CC       phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via
CC       the condensation of PEP with GTP. It is involved in the biosynthesis of
CC       coenzyme F420, a hydride carrier cofactor.
else case <OC:Pseudomonadota>
CC   -!- FUNCTION: Guanylyltransferase that catalyzes the activation of (2R)-3-
CC       phosphoglycerate (3PG) as 3-[(R)-glyceryl]-diphospho-5'-guanosine, via
CC       the condensation of 3PG with GTP. It is involved in the biosynthesis of
CC       a derivative of the hydride carrier cofactor coenzyme F420, 3PG-F420.
else
CC   -!- FUNCTION: Guanylyltransferase that catalyzes the activation of
CC       phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via
CC       the condensation of PEP with GTP. It is involved in the biosynthesis of
CC       coenzyme F420, a hydride carrier cofactor.
end case
case <OC:Archaea>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-
CC         5'-guanosine + diphosphate; Xref=Rhea:RHEA:63424, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:59435,
CC         ChEBI:CHEBI:59906; EC=2.7.7.68;
else case <OC:Actinomycetota>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-
CC         2-diphospho-5'-guanosine; Xref=Rhea:RHEA:30519, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58702,
CC         ChEBI:CHEBI:143701; EC=2.7.7.105;
else case <OC:Pseudomonadota>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-
CC         diphospho-5'-guanosine + diphosphate; Xref=Rhea:RHEA:63440,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:58272, ChEBI:CHEBI:147306; EC=2.7.7.106;
else
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-
CC         2-diphospho-5'-guanosine; Xref=Rhea:RHEA:30519, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58702,
CC         ChEBI:CHEBI:143701; EC=2.7.7.105;
end case
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
case <OC:Archaea>
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SIMILARITY: Belongs to the CofC family.
XX
DR   Pfam; PF01983; CofC; 1; trigger=no
DR   NCBIfam; TIGR03552; F420_cofC; 1; trigger=no
XX
KW   GTP-binding
KW   Nucleotide-binding
KW   Nucleotidyltransferase
KW   Transferase
XX
GO   GO:0070568; F:guanylyltransferase activity
GO   GO:0052645; P:F420-0 metabolic process
XX
case <OC:Actinomycetota>
FT   From: FBID_MYCTU (P9WP83)
FT   BINDING         148
FT                   /ligand="phosphoenolpyruvate"
FT                   /ligand_id="ChEBI:CHEBI:58702"
FT   Condition: T
FT   BINDING         163
FT                   /ligand="phosphoenolpyruvate"
FT                   /ligand_id="ChEBI:CHEBI:58702"
FT   Optional; Condition: G
FT   BINDING         166
FT                   /ligand="phosphoenolpyruvate"
FT                   /ligand_id="ChEBI:CHEBI:58702"
FT   Condition: S
end case
XX
Size: 190-316;
Related: None;
Template: P9WP83; Q58297; A0QUZ4; Q8PU52; E5ASS2;
Scope:
 Bacteria; Actinomycetota
 Bacteria; Chloroflexota
 Bacteria; Pseudomonadota
 Bacteria; Thermobaculum
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in RHOJR
Plasmid: in RHOJR, THERP
Comments: None
XX
# Revision 1.17 2023/06/01
//