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HAMAP rule MF_03059

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General rule information [?]

Accession MF_03059
Dates 4-SEP-2009 (Created)
1-JUN-2023 (Last updated, Version 11)
Name mEF_G_2
Scope(s) Eukaryota
Template(s) Q969S9 (RRF2M_HUMAN); P39677 (RRF2M_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03059 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RRF2M
Protein name RecName: Full=Ribosome-releasing factor 2, mitochondrial;
                 Short=RRF2mt;
AltName: Full=Elongation factor G 2, mitochondrial;
                 Short=mEF-G 2;
                 Short=EF-G2mt;
case <OC:Vertebrata>
Gene name Name=GFM2; Synonyms=EFG2;
else case <OC:Fungi>
Gene name Name=MEF2;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONMitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with @gn(MRRF). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
else
FUNCTIONMitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
end case
SUBCELLULAR LOCATIONMitochondrion.
case not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITYBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003924; Molecular function:GTPase activity
GO:0005525; Molecular function:GTP binding
GO:0032543; Biological process:mitochondrial translation
GO:0032790; Biological process:ribosome disassembly
GO:0005739; Cellular component:mitochondrion

Cross-references [?]

PROSITE PS00301; G_TR_1; 1;
PROSITE PS51722; G_TR_2; 1;
Pfam PF00679; EFG_C; 1;
Pfam PF03764; EFG_IV; 1;
Pfam PF00009; GTP_EFTU; 1;
Pfam PF03144; GTP_EFTU_D2; 1;
PRINTS PR00315; ELONGATNFCT; 1;
NCBIfam TIGR00231; small_GTP; 1;
General TransitM; -; 0-1;

Features [?]

From: RRF2M_HUMAN (Q969S9)
Key From To Description Tag Condition FTGroup
BINDING 77 84 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
A-H-I-D-[AG]-G-K-T
BINDING 141 145 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
D-T-P-G-H
BINDING 195 198 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
N-K-[ML]-D

Additional information [?]

Size range 692-931 amino acids
Related rules None
Fusion Nter: None Cter: None



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