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HAMAP rule MF_03108

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General rule information [?]

Accession MF_03108
Dates 14-AUG-2009 (Created)
7-DEC-2023 (Last updated, Version 13)
Name Catal-peroxid_euk
Scope(s) Eukaryota
Fungi
Template(s) A4QUT2 (KATG2_PYRO7); A4R5S9 (KATG1_PYRO7); Q8X182 (KATG_NEUCR); Q96VT4 (KATG_EMENI); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_01961 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KATG
Protein name RecName: Full=Catalase-peroxidase;
                 Short=CP;
                 EC=1.11.1.21;
AltName: Full=Peroxidase/catalase;
Gene name Name=katG;

Comments [?]

case <Feature:Signal==1>
FUNCTIONBifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection.
else
FUNCTIONBifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
end case
CATALYTIC ACTIVITY Reaction=AH2 + H2O2 = A + 2 H2O; Xref=Rhea:RHEA:30275, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:17499; EC=1.11.1.21;
CATALYTIC ACTIVITY Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.21;
COFACTOR Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.;
case <Feature:Signal==1>
SUBUNITHomodimer; disulfide-linked.
SUBCELLULAR LOCATIONSecreted.
else
SUBUNITHomodimer or homotetramer.
SUBCELLULAR LOCATIONCytoplasm.
end case
PTMFormation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
SIMILARITYBelongs to the peroxidase family. Peroxidase/catalase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004096; Molecular function:catalase activity
GO:0004601; Molecular function:peroxidase activity

Cross-references [?]

PROSITE PS00435; PEROXIDASE_1; 1;
PROSITE PS00436; PEROXIDASE_2; 1;
PROSITE PS50873; PEROXIDASE_4; 1;
Pfam PF00141; peroxidase; 2;
PRINTS PR00460; BPEROXIDASE; 1;
PRINTS PR00458; PEROXIDASE; 1;
NCBIfam TIGR00198; cat_per_HPI; 1;
General Signal; -; 0-1;

Features [?]

From: KATG2_PYRO7 (A4QUT2)
Key From To Description Tag Condition FTGroup
ACT_SITE 141 141 /note="Proton acceptor" H
BINDING 314 314 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"
H
SITE 137 137 /note="Transition state stabilizer" R
CROSSLNK 140 273 /note="Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with #{Met-299})" W-x*-Y
CROSSLNK 273 299 /note="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with #{Trp-140})" Y-x*-M
case <Feature:Signal==1>
DISULFID 55 55 /note="Interchain (with #{Cys-74})" C
DISULFID 74 74 /note="Interchain (with #{Cys-55})" C
end case

Additional information [?]

Size range 730-786 amino acids
Related rules None
Fusion Nter: None Cter: None



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