HAMAP rule MF_03108
General rule information
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Accession | MF_03108 |
Dates | 14-AUG-2009 (Created)
7-DEC-2023 (Last updated, Version 13) |
Name | Catal-peroxid_euk |
Scope(s) |
Eukaryota Fungi |
Template(s) | A4QUT2 (KATG2_PYRO7); A4R5S9 (KATG1_PYRO7); Q8X182 (KATG_NEUCR); Q96VT4 (KATG_EMENI); [ Recover all ] |
Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01961 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | KATG |
Protein name | RecName: Full=Catalase-peroxidase; Short=CP; EC=1.11.1.21; AltName: Full=Peroxidase/catalase; |
Gene name | Name=katG; |
Comments
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case <Feature:Signal==1> | |
FUNCTION | Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection. |
else | |
FUNCTION | Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. |
end case | |
CATALYTIC ACTIVITY | Reaction=AH2 + H2O2 = A + 2 H2O; Xref=Rhea:RHEA:30275, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:17499; EC=1.11.1.21; |
CATALYTIC ACTIVITY | Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.21; |
COFACTOR | Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.; |
case <Feature:Signal==1> | |
SUBUNIT | Homodimer; disulfide-linked. |
SUBCELLULAR LOCATION | Secreted. |
else | |
SUBUNIT | Homodimer or homotetramer. |
SUBCELLULAR LOCATION | Cytoplasm. |
end case | |
PTM | Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme. |
SIMILARITY | Belongs to the peroxidase family. Peroxidase/catalase subfamily. |
Keywords
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Heme | |
Hydrogen peroxide | |
Iron | |
Metal-binding | |
Oxidoreductase | |
Peroxidase | |
case <Feature:Signal==1> | |
Disulfide bond | |
Secreted | |
else | |
Cytoplasm | |
end case |
Gene Ontology
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GO:0004096; Molecular function:catalase activity |
GO:0004601; Molecular function:peroxidase activity |
Cross-references
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PROSITE | PS00435; PEROXIDASE_1; 1; |
PROSITE | PS00436; PEROXIDASE_2; 1; |
PROSITE | PS50873; PEROXIDASE_4; 1; |
Pfam | PF00141; peroxidase; 2; |
PRINTS | PR00460; BPEROXIDASE; 1; |
PRINTS | PR00458; PEROXIDASE; 1; |
NCBIfam | TIGR00198; cat_per_HPI; 1; |
General | Signal; -; 0-1; |
Features
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From: KATG2_PYRO7 (A4QUT2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 141 | 141 | /note="Proton acceptor" | H | ||||||||
BINDING | 314 | 314 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
SITE | 137 | 137 | /note="Transition state stabilizer" | R | ||||||||
CROSSLNK | 140 | 273 | /note="Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with #{Met-299})" | W-x*-Y | ||||||||
CROSSLNK | 273 | 299 | /note="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with #{Trp-140})" | Y-x*-M | ||||||||
case <Feature:Signal==1> | ||||||||||||
DISULFID | 55 | 55 | /note="Interchain (with #{Cys-74})" | C | ||||||||
DISULFID | 74 | 74 | /note="Interchain (with #{Cys-55})" | C | ||||||||
end case |
Additional information
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Size range | 730-786 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |