HAMAP rule MF_03217
General rule information
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Accession | MF_03217 |
Dates | 11-JUL-2016 (Created)
20-NOV-2019 (Last updated, Version 4) |
Name | PEMT |
Scope(s) |
Eukaryota Fungi |
Template(s) | P05374 (CHO2_YEAST); Q7SAJ6 (CHO2_NEUCR); [ Recover all ] |
Triggered by |
HAMAP; MF_03217 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | CHO2 |
Protein name | RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PE methyltransferase; Short=PEAMT; Short=PEMT; EC=2.1.1.17; |
Comments
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FUNCTION | Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME). |
CATALYTIC ACTIVITY | Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L- methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11164, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17; |
PATHWAY | Phospholipid metabolism; phosphatidylcholine biosynthesis. |
SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
SIMILARITY | Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family. |
Keywords
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Gene Ontology
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GO:0005789; Cellular component:endoplasmic reticulum membrane |
GO:0004608; Molecular function:phosphatidylethanolamine N-methyltransferase activity |
GO:0006656; Biological process:phosphatidylcholine biosynthetic process |
Cross-references
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PROSITE | PS51598; SAM_CHO2; 1; |
PROSITE | PS50244; S5A_REDUCTASE; 0-1; |
Pfam | PF04191; PEMT; 2; |
PIRSF | PIRSF000383; PEAMT; 1; |
General | Transmembrane; -; 11; |
ADD_TOPO_DOMAIN | Lumenal; -; 6; |
ADD_TOPO_DOMAIN | Cytoplasmic; -; 6; |
Features
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Additional information
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Size range | 837-1077 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |