HAMAP rule MF_04046
General rule information
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| Accession | MF_04046 |
| Dates | 10-NOV-2016 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | HSV_UNG |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P10186 (UNG_HHV11); P12295 (UNG_ECOLI); [ Recover all ] |
| Triggered by |
case c? <OC:Herpesviridae>
HAMAP; MF_00148 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | UNG |
| Protein name | RecName: Full=Uracil-DNA glycosylase; Short=UDG; EC=3.2.2.27; AltName: Full=UNG; |
Comments
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| FUNCTION | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes. |
| CATALYTIC ACTIVITY | Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27; |
| SUBCELLULAR LOCATION | Host nucleus. |
| SIMILARITY | Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. |
Keywords
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Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0004844; Molecular function:uracil DNA N-glycosylase activity |
| GO:0006284; Biological process:base-excision repair |
Cross-references
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Features
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| From: UNG_ECOLI (P12295) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 64 | 64 | /note="Proton acceptor" | D | ||||||||
Additional information
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| Size range | 204-362 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |