HAMAP rule MF_04047

General rule information [?]

Accession	MF_04047
Dates	13-FEB-2017 (Created) 20-NOV-2019 (Last updated, Version 4)
Name	ADV_CAP3
Scope(s)	Viruses Adenoviridae
Template(s)	P12537 (CAP3_ADE05); [ Recover all ]
Triggered by	HAMAP; MF_04047 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CAP3
Protein name	RecName: Full=Pre-hexon-linking protein IIIa; AltName: Full=Capsid vertex-specific component IIIa; Short=CVSC; AltName: Full=Protein IIIa; AltName: Full=pIIIa; Contains: RecName: Full=Hexon-linking protein IIIa;

Comments [?]

FUNCTION	Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.
SUBUNIT	Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.
SUBCELLULAR LOCATION	Virion. Host nucleus. Note=Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.
INDUCTION	Expressed in the late phase of the viral replicative cycle.
PTM	Cleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.
MISCELLANEOUS	All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
SIMILARITY	Belongs to the adenoviridae hexon-linking protein IIIa family.

Keywords [?]

Capsid decoration protein

Viral genome packaging

Virion

Viral release from host cell

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus

GO:0019028; Cellular component:viral capsid

GO:0098021; Cellular component:viral capsid, decoration

Cross-references [?]

Pfam	PF02455; Hex_IIIa; 1;

Features [?]

From: CAP3_ADE05 (P12537)

Key

From

Description

Tag

Condition

FTGroup

CHAIN

Nter

Cter

/note="Pre-hexon-linking protein IIIa"

CHAIN

Nter

570

/note="Hexon-linking protein IIIa"

PROPEP

571

Cter

REGION

Nter

106

/note="Peripentonal hexon-tethering domain"

REGION

138

251

/note="Binding to hexon-linking protein"

SITE

570

571

/note="Cleavage; by viral protease"

MOD_RES

225