HAMAP rule MF_04049
General rule information
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| Accession | MF_04049 |
| Dates | 6-MAR-2017 (Created)
15-OCT-2021 (Last updated, Version 5) |
| Name | ADV_CAP8 |
| Scope(s) |
Viruses Adenoviridae |
| Template(s) | P24936 (CAP8_ADE05); [ Recover all ] |
| Triggered by |
HAMAP; MF_04049 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CAP8 |
| Protein name | RecName: Full=Pre-hexon-linking protein VIII; AltName: Full=Pre-protein VIII; Short=pVIII; Contains: RecName: Full=Hexon-linking protein-N; AltName: Full=12.1 kDa protein VIII; AltName: Full=Protein VIII-N; Contains: RecName: Full=Hexon-linking protein-C; AltName: Full=7.6 kDa protein VIII; AltName: Full=Protein VIII-C; |
| Gene name | Name=L4; |
Comments
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| FUNCTION | Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together. |
| FUNCTION | Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together. |
| SUBUNIT | Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid. |
| SUBCELLULAR LOCATION | Pre-hexon-linking protein VIII: Host nucleus. |
| SUBCELLULAR LOCATION | Hexon-linking protein-N: Virion. Note=Located on the inner side of the capsid shell. Present in 120 copies per virion. |
| SUBCELLULAR LOCATION | Hexon-linking protein-C: Virion. Note=Located on the inner side of the capsid shell. Present in 120 copies per virion. |
| INDUCTION | Expressed in the late phase of the viral replicative cycle. |
| PTM | Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid. |
| MISCELLANEOUS | All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell. |
| SIMILARITY | Belongs to the adenoviridae hexon-linking protein family. |
Keywords
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Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0019028; Cellular component:viral capsid |
Cross-references
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| Pfam | PF01310; Adeno_PVIII; 1; |
Features
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| From: CAP8_ADE05 (P24936) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| CHAIN | Nter | Cter | /note="Pre-hexon-linking protein VIII" | |||||||||
| PEPTIDE | Nter | 111 | /note="Hexon-linking protein-N" | |||||||||
| PROPEP | 112 | 157 | ||||||||||
| PEPTIDE | 158 | Cter | /note="Hexon-linking protein-C" | |||||||||
| SITE | 111 | 112 | /note="Cleavage; by viral protease" | |||||||||
| SITE | 157 | 158 | /note="Cleavage; by viral protease" | |||||||||
| MOD_RES | 64 | 64 | /note="Phosphothreonine; by host" | T | ||||||||
| MOD_RES | 118 | 118 | /note="Phosphoserine; by host" | S | ||||||||
| MOD_RES | 174 | 174 | /note="Phosphoserine; by host" | S | ||||||||
Additional information
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| Size range | 155-278 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |