HAMAP rule MF_04054
General rule information
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| Accession | MF_04054 |
| Dates | 10-MAR-2017 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | ADV_DNB2 |
| Scope(s) |
Viruses Adenoviridae |
| Template(s) | P03265 (DNB2_ADE05); [ Recover all ] |
| Triggered by |
HAMAP; MF_04054 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DNB2 |
| Protein name | RecName: Full=DNA-binding protein; Short=DBP; AltName: Full=Early 2A protein; AltName: Full=Early E2A DNA-binding protein; |
| Gene name | Name=DBP; |
Comments
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| FUNCTION | Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP- independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP. |
| SUBUNIT | Homomultimerizes on viral ssDNA bound to pTP. Forms a initiation complex with viral polymerase, pTP and hosts NFIA and POU2F1/OCT1. Interacts with host SRCAP. |
| SUBCELLULAR LOCATION | Host nucleus. Note=Accumulates in infected cells. |
| DOMAIN | The C-terminal arm bridges DBP molecules together, thereby creating a chain. |
| SIMILARITY | Belongs to the adenoviridae E2A DNA-binding protein family. |
Keywords
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| DNA replication |
| DNA-binding |
| Early protein |
| Host nucleus |
| Host-virus interaction |
| Metal-binding |
| Phosphoprotein |
| Viral DNA replication |
| Zinc |
Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0019028; Cellular component:viral capsid |
| GO:0003677; Molecular function:DNA binding |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0032508; Biological process:DNA duplex unwinding |
| GO:0045740; Biological process:positive regulation of DNA replication |
| GO:0006351; Biological process:DNA-templated transcription |
| GO:0039693; Biological process:viral DNA genome replication |
| GO:0039687; Biological process:viral DNA strand displacement replication |
Cross-references
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Features
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| From: DNB2_ADE05 (P03265) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 297 | 331 | /note="Flexible loop" | |||||||||
| REGION | 513 | Cter | /note="C-terminal arm, DBP binding" | |||||||||
| BINDING | 284 | 284 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
C | ||||||||
| BINDING | 286 | 286 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 339 | 339 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
C | ||||||||
| BINDING | 355 | 355 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
C | ||||||||
| BINDING | 396 | 396 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
| BINDING | 398 | 398 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
| BINDING | 450 | 450 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
| BINDING | 467 | 467 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
| MOD_RES | 195 | 195 | /note="Phosphotyrosine; by host" | Y | ||||||||
Additional information
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| Size range | 397-529 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |