AC   MF_00023;
DC   Protein; auto
TR   HAMAP; MF_00023; -; 1; level=0
XX
Names: SmpB
XX
ID   SSRP
DE   RecName: Full=SsrA-binding protein;
DE   AltName: Full=Small protein B;
GN   Name=smpB;
XX
CC   -!- FUNCTION: Required for rescue of stalled ribosomes mediated by trans-
CC       translation. Binds to transfer-messenger RNA (tmRNA), required for
CC       stable association of tmRNA with ribosomes. tmRNA and SmpB together
CC       mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is
CC       encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and
CC       it encodes a 'tag peptide', a short internal open reading frame. During
CC       trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering
CC       the A-site of stalled ribosomes, displacing the stalled mRNA. The
CC       ribosome then switches to translate the ORF on the tmRNA; the nascent
CC       peptide is terminated with the 'tag peptide' encoded by the tmRNA and
CC       targeted for degradation. The ribosome is freed to recommence
CC       translation, which seems to be the essential function of trans-
CC       translation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=The tmRNA-SmpB complex associates
CC       with stalled 70S ribosomes.
CC   -!- SIMILARITY: Belongs to the SmpB family.
XX
DR   Pfam; PF01668; SmpB; 1; trigger=no
DR   NCBIfam; TIGR00086; smpB; 1; trigger=no
DR   PROSITE; PS01317; SSRP; 1; trigger=no
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KW   Cytoplasm
KW   RNA-binding
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GO   GO:0003723; F:RNA binding
GO   GO:0005737; C:cytoplasm
GO   GO:0070929; P:trans-translation
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FT   None
XX
Size: 120-221;
Related: None;
Template: P0A832; Q8RR57; O66640; O32230;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.26 2023/06/01
//