AC   MF_00031;
DC   Protein; auto
TR   HAMAP; MF_00031; -; 1; level=0
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Names: DNA_HJ_migration_RuvA
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ID   RUVA
DE   RecName: Full=Holliday junction branch migration complex subunit RuvA;
GN   Name=ruvA;
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CC   -!- FUNCTION: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ)
CC       DNA during genetic recombination and DNA repair, while the RuvA-RuvB
CC       complex plays an important role in the rescue of blocked DNA
CC       replication forks via replication fork reversal (RFR). RuvA
CC       specifically binds to HJ cruciform DNA, conferring on it an open
CC       structure. The RuvB hexamer acts as an ATP-dependent pump, pulling
CC       dsDNA into and through the RuvAB complex. HJ branch migration allows
CC       RuvC to scan DNA until it finds its consensus sequence, where it
CC       cleaves and resolves the cruciform DNA.
CC   -!- SUBUNIT: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ)
CC       complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters
CC       through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA
CC       strand where it exits the tetramer. Each RuvB hexamer is contacted by
CC       two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this
CC       complex drives branch migration. In the full resolvosome a probable
CC       DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: Has three domains with a flexible linker between the domains II
CC       and III and assumes an 'L' shape. Domain III is highly mobile and
CC       contacts RuvB.
CC   -!- SIMILARITY: Belongs to the RuvA family.
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DR   Pfam; PF07499; RuvA_C; 1; trigger=no
DR   Pfam; PF01330; RuvA_N; 1; trigger=no
DR   NCBIfam; TIGR00084; ruvA; 1; trigger=no
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KW   Cytoplasm
KW   DNA damage
KW   DNA repair
case <OC:Escherichia>
KW   SOS response
end case
KW   DNA-binding
KW   DNA recombination
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GO   GO:0005737; C:cytoplasm
GO   GO:0000400; F:four-way junction DNA binding
GO   GO:0048476; C:Holliday junction resolvase complex
GO   GO:0006310; P:DNA recombination
GO   GO:0006281; P:DNA repair
case <OC:Escherichia>
GO   GO:0009432; P:SOS response
end case
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FT   From: RUVA_ECOLI (P0A809)
FT   REGION          1..64
FT                   /note="Domain I"
FT   REGION          65..142
FT                   /note="Domain II"
FT   REGION          143..155
FT                   /note="Flexible linker"
FT   REGION          156..Cter
FT                   /note="Domain III"
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Size: 150-250;
Related: None;
Template: P0A809; P40832; Q9F1Q3; P9WGW3; P66746;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.29 2023/06/01
//