AC   MF_00033;
DC   Protein; auto
TR   HAMAP; MF_00033; -; 1; level=0
XX
Names: MurG
XX
ID   MURG
DE   RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;
DE            EC=2.4.1.227;
DE   AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;
GN   Name=murG;
XX
CC   -!- FUNCTION: Cell wall formation. Catalyzes the transfer of a GlcNAc
CC       subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid
CC       intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-
CC       (pentapeptide)GlcNAc (lipid intermediate II).
case <OC:Lactobacillales> or <OC:Staphylococcus>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC         cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine =
CC         beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-
CC         di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP;
CC         Xref=Rhea:RHEA:23192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:58223, ChEBI:CHEBI:60032, ChEBI:CHEBI:60033;
CC         EC=2.4.1.227;
else
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-
CC         muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-
CC         alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-
CC         undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-
CC         acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-
CC         D-alanyl-D-alanine + H(+) + UDP; Xref=Rhea:RHEA:31227,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:61387, ChEBI:CHEBI:61388; EC=2.4.1.227;
end case
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
end case
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 28 family. MurG
CC       subfamily.
XX
DR   Pfam; PF04101; Glyco_tran_28_C; 1; trigger=no
DR   Pfam; PF03033; Glyco_transf_28; 1; trigger=no
DR   NCBIfam; TIGR01133; MurG; 1; trigger=no
XX
KW   Cell cycle
KW   Cell division
KW   Cell membrane
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Glycosyltransferase
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Membrane
KW   Peptidoglycan synthesis
KW   Transferase
XX
GO   GO:0050511; F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
GO   GO:0030259; P:lipid glycosylation
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: MURG_PSEAE (Q9HW01)
FT   BINDING         12..14
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: [TS]-[GA]-G
FT   BINDING         262..267
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: [AG]-L-[TS]-V-x-[ED]
FT   BINDING         124
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: N
FT   BINDING         163
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: R
FT   BINDING         189
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: S
FT   BINDING         243
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: I
FT   BINDING         288
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: Q
XX
Size: 333-441;
Related: None;
Template: P17443; Q9HW01;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAH, BACAN, BACC1, BACCR, BACCZ, BACHK
Plasmid: None
Comments: None
XX
# Revision 1.50 2023/06/01
//