AC MF_00034; DC Protein; auto TR HAMAP; MF_00034; -; 1; level=0 XX Names: RuvC XX ID RUVC DE RecName: Full=Crossover junction endodeoxyribonuclease RuvC; DE EC=3.1.21.10; DE AltName: Full=Holliday junction nuclease RuvC; DE AltName: Full=Holliday junction resolvase RuvC; GN Name=ruvC; XX CC -!- FUNCTION: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) CC DNA during genetic recombination and DNA repair. Endonuclease that CC resolves HJ intermediates. Cleaves cruciform DNA by making single- CC stranded nicks across the HJ at symmetrical positions within the CC homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; CC requires a central core of homology in the junction. The consensus CC cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side CC of the TT dinucleotide at the point of strand exchange. HJ branch CC migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it CC finds its consensus sequence, where it cleaves and resolves the CC cruciform DNA. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage at a junction such as a reciprocal CC single-stranded crossover between two homologous DNA duplexes CC (Holliday junction).; EC=3.1.21.10; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Note=Binds 2 Mg(2+) ion per subunit.; CC -!- SUBUNIT: Homodimer which binds Holliday junction (HJ) DNA. The HJ CC becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it CC has a different conformation from HJ DNA in complex with RuvA. In the CC full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms CC which resolves the HJ. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the RuvC family. XX DR Pfam; PF02075; RuvC; 1; trigger=no DR NCBIfam; TIGR00228; ruvC; 1; trigger=no DR PROSITE; PS01321; RUVC; 1; trigger=no XX KW Cytoplasm KW Endonuclease KW Hydrolase KW Nuclease KW DNA damage KW DNA repair KW DNA recombination KW DNA-binding KW Magnesium KW Metal-binding XX GO GO:0005737; C:cytoplasm GO GO:0048476; C:Holliday junction resolvase complex GO GO:0008821; F:crossover junction DNA endonuclease activity GO GO:0000287; F:magnesium ion binding GO GO:0006310; P:DNA recombination GO GO:0006281; P:DNA repair XX FT From: RUVC_THET8 (Q5SJC4) FT ACT_SITE 7 FT Condition: D FT ACT_SITE 70 FT Condition: E FT ACT_SITE 143 FT Condition: [HD] FT BINDING 7 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT Condition: D FT BINDING 70 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT Condition: E FT BINDING 143 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT Condition: [HD] XX Size: 100-300; Related: None; Template: Q5SJC4; P0A814; Q51424; Q9RX75; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.35 2023/06/01 //