AC   MF_00038;
DC   Protein; auto
TR   HAMAP; MF_00038; -; 1; level=0
XX
Names: MraY
XX
ID   MRAY
case <OC:Bacteria>
DE   RecName: Full=Phospho-N-acetylmuramoyl-pentapeptide-transferase;
DE            EC=2.7.8.13;
DE   AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
GN   Name=mraY;
else case <OC:Archaea>
DE   RecName: Full=Putative phospho-N-acetylmuramoyl-pentapeptide-transferase;
DE            EC=2.7.8.13;
DE   AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
end case
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Catalyzes the initial step of the lipid cycle reactions in
CC       the biosynthesis of the cell wall peptidoglycan: transfers
CC       peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-
CC       pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding
CC       undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
end case
case <OC:Lactobacillales> or <OC:Staphylococcus>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-
CC         D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine =
CC         Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-
CC         undecaprenyl diphosphate + UMP; Xref=Rhea:RHEA:21920,
CC         ChEBI:CHEBI:57865, ChEBI:CHEBI:60032, ChEBI:CHEBI:60392,
CC         ChEBI:CHEBI:70758; EC=2.7.8.13;
else
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-
CC         D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-
CC         alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-
CC         alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-
CC         alanyl-D-alanine + UMP; Xref=Rhea:RHEA:28386, ChEBI:CHEBI:57865,
CC         ChEBI:CHEBI:60392, ChEBI:CHEBI:61386, ChEBI:CHEBI:61387; EC=2.7.8.13;
end case
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Bacteria>
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 4 family. MraY
CC       subfamily.
XX
DR   Pfam; PF00953; Glycos_transf_4; 1; trigger=no
DR   NCBIfam; TIGR00445; MraY; 1; trigger=no
DR   PROSITE; PS01347; MRAY_1; 1; trigger=no
DR   PROSITE; PS01348; MRAY_2; 1; trigger=no
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
DR   General; Transmembrane; -; 10; trigger=yes
DR   ADD_TOPO_DOMAIN; Periplasmic; -; 6; trigger=yes
DR   ADD_TOPO_DOMAIN; Cytoplasmic; -; 5; trigger=yes
else
DR   General; Transmembrane; -; 8-11; trigger=yes
end case
XX
case <OC:Bacteria>
KW   Cell cycle
KW   Cell division
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Peptidoglycan synthesis
end case
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Magnesium
KW   Membrane
KW   Metal-binding
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0008963; F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity
case <OC:Bacteria>
GO   GO:0009252; P:peptidoglycan biosynthetic process
end case
GO   GO:0005886; C:plasma membrane
XX
FT   None
XX
Size: 302-422;
Related: None;
Template: P0A6W3; Q2FZ93; O66465;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Very divergent TREPA
XX
# Revision 1.51 2023/06/01
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