AC   MF_00039;
DC   Protein; auto
c?   <OC:Archaea>
TR   HAMAP; MF_00039; -; 1; level=0
XX
Names: Adenylate_kinase_AK6
XX
ID   KAD6
DE   RecName: Full=Putative adenylate kinase;
DE            Short=AK;
DE            EC=2.7.4.3;
DE   AltName: Full=ATP-AMP transphosphorylase;
XX
CC   -!- FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that
CC       catalyzes the reversible transfer of the terminal phosphate group
CC       between nucleoside triphosphates and monophosphates. Has also ATPase
CC       activity. Involved in the late maturation steps of the 30S ribosomal
CC       particles, specifically 16S rRNA maturation. While NMP activity is not
CC       required for ribosome maturation, ATPase activity is. Associates
CC       transiently with small ribosomal subunit protein uS11. ATP hydrolysis
CC       breaks the interaction with uS11. May temporarily remove uS11 from the
CC       ribosome to enable a conformational change of the ribosomal RNA that is
CC       needed for the final maturation step of the small ribosomal subunit.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC   -!- SUBUNIT: Interacts with uS11. Not a structural component of 40S pre-
CC       ribosomes, but transiently interacts with them by binding to uS11.
CC   -!- SIMILARITY: Belongs to the adenylate kinase family. AK6 subfamily.
XX
KW   ATP-binding
KW   Nucleotide-binding
KW   Kinase
KW   Transferase
KW   Ribosome biogenesis
KW   rRNA processing
XX
GO   GO:0004017; F:adenylate kinase activity
GO   GO:0005524; F:ATP binding
GO   GO:0042274; P:ribosomal small subunit biogenesis
XX
FT   From: KAD6_PYRAB (Q9UZK4)
FT   REGION          30..50
FT                   /note="NMP"
FT   REGION          99..109
FT                   /note="LID"
FT   BINDING         10
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G
FT   BINDING         12
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G
FT   BINDING         13
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
FT   BINDING         14
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [ST]
FT   BINDING         15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [STIVY]
FT   BINDING         100
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: R
FT   BINDING         138
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
XX
Size: 148-196;
Related: None;
Template: Q9UZK4; Q9Y3D8;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Has homologs in eukaryotes
XX
# Revision 1.29 2023/11/23
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