AC   MF_00042;
DC   Protein; auto
TR   HAMAP; MF_00042; -; 1; level=0
XX
Names: RNase_H
XX
ID   RNH
DE   RecName: Full=Ribonuclease H;
DE            Short=RNase H;
DE            EC=3.1.26.4;
GN   Name=rnhA;
XX
CC   -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA
CC       hybrids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a
CC       regulatory site, or after substrate binding.;
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the RNase H family.
XX
DR   Pfam; PF00075; RNase_H; 1; trigger=no
DR   PROSITE; PS50879; RNASE_H_1; 1; trigger=yes
XX
KW   Cytoplasm
KW   Hydrolase
KW   Nuclease
KW   Endonuclease
KW   Magnesium
KW   Metal-binding
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0004523; F:RNA-DNA hybrid ribonuclease activity
GO   GO:0006401; P:RNA catabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: RNH_ECOLI (P0A7Y4)
FT   BINDING         10
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         10
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         48
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         70
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         134
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
XX
Size: 143-231;
Related: None;
Template: P0A7Y4; P29253;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Possible C-terminal domain in STRCO.
 Divergence in TREPA.
XX
# Version: 27
# Last updated date: 2022-11-19
# Created date: 2005-02-28
//