AC   MF_00046;
DC   Protein; auto
TR   HAMAP; MF_00046; -; 1; level=0
XX
Names: MurC
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ID   MURC
DE   RecName: Full=UDP-N-acetylmuramate--L-alanine ligase;
DE            EC=6.3.2.8;
DE   AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase;
GN   Name=murC;
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CC   -!- FUNCTION: Cell wall formation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) +
CC         phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine;
CC         Xref=Rhea:RHEA:23372, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57972, ChEBI:CHEBI:70757,
CC         ChEBI:CHEBI:83898, ChEBI:CHEBI:456216; EC=6.3.2.8;
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MurCDEF family.
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DR   Pfam; PF01225; Mur_ligase; 1; trigger=no
DR   Pfam; PF02875; Mur_ligase_C; 1; trigger=no
DR   NCBIfam; TIGR01082; MurC; 1; trigger=no
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KW   ATP-binding
KW   Cell cycle
KW   Cell division
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Cytoplasm
KW   Ligase
KW   Nucleotide-binding
KW   Peptidoglycan synthesis
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GO   GO:0005524; F:ATP binding
GO   GO:0008763; F:UDP-N-acetylmuramate-L-alanine ligase activity
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: MURC_ECOLI (P17952)
FT   BINDING         126..132
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x(2)-G-K-[ST]-[STG]
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Size: 431-539;
Related: MF_00208;
Template: P17952; Q9WY73;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: MF_00047 (ddl)
Duplicate: None
Plasmid: None
Comments: Weird insertion in NOSS1 and SYNY3.
 Probable wrong start in LACLA.
XX
# Revision 1.43 2023/06/01
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