AC   MF_00049;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_00049_B; -; 1; level=0
c?   <OC:Archaea>
TR   HAMAP; MF_00049_A; -; 1; level=0
XX
Names: Leu_tRNA_synth
XX
ID   SYL
DE   RecName: Full=Leucine--tRNA ligase;
DE            EC=6.1.1.4;
DE   AltName: Full=Leucyl-tRNA synthetase;
DE            Short=LeuRS;
GN   Name=leuS;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC         tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC         COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
XX
DR   Pfam; PF00133; tRNA-synt_1; 1; trigger=no
DR   PRINTS; PR00985; TRNASYNTHLEU; 1; trigger=no
DR   NCBIfam; TIGR00395; LeuS_arch; 1; trigger=no
DR   NCBIfam; TIGR00396; LeuS_bact; 1; trigger=no
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1; trigger=no
XX
KW   Cytoplasm
KW   Aminoacyl-tRNA synthetase
KW   Protein biosynthesis
KW   Ligase
KW   ATP-binding
KW   Nucleotide-binding
XX
GO   GO:0005524; F:ATP binding
GO   GO:0004823; F:leucine-tRNA ligase activity
GO   GO:0006429; P:leucyl-tRNA aminoacylation
GO   GO:0005737; C:cytoplasm
XX
FT   From: SYL_ECOLI (P07813)
case <OC:Bacteria>
FT   MOTIF           42..52
FT                   /note="'HIGH' region"
FT   Condition: [SP]-[YF]-[PLVT]-[SN]-[GAS]-x(1,3)-H-[LIVMA]-G-[HS]
FT   MOTIF           619..623
FT                   /note="'KMSKS' region"
FT   Condition: [KRTA]-[MLI]-[SGA]-[KS]-[SA]
FT   BINDING         622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
end case
FT   From: SYL_METJA (Q58050)
case <OC:Archaea>
FT   MOTIF           41..51
FT                   /note="'HIGH' region"
FT   Condition: P-Y-x-[SN]-[GAS]-x(2)-H-[LIVMA]-G-[HS]
FT   MOTIF           633..637
FT                   /note="'KMSKS' region"
FT   BINDING         636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
end case
XX
case <OC:Bacteria>
Size: 792-990;
end case
case <OC:Archaea>
Size: 910-977;
end case
Related: None;
Template: P07813;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in RHIJ3, METS5, SACS2, SULTO
Plasmid: None
Comments: The AQUAE leuS is cut into two subunits. It is not shown in the alignment.
 There is a shorter second copy in SULTO, which is not shown in the
 alignment, nor are HALSA or NANEQ as they are quite divergent.
XX
# Revision 1.37 2023/11/28
//