AC MF_00052; DC Protein; auto c? TR HAMAP; MF_00052_B; -; 1; level=0 c? TR HAMAP; MF_00052_A; -; 1; level=0 XX Names: RNase_HII XX ID RNH2 DE RecName: Full=Ribonuclease HII; DE Short=RNase HII; DE EC=3.1.26.4; GN Name=rnhB; XX CC -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA CC hybrids. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in CC the absence of substrate. May bind a second metal ion after substrate CC binding.; CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the RNase HII family. XX DR PROSITE; PS51975; RNASE_H_2; 1; trigger=yes DR Pfam; PF01351; RNase_HII; 1; trigger=no DR NCBIfam; TIGR00729; TIGR00729; 1; trigger=no XX KW Cytoplasm KW Hydrolase KW Nuclease KW Endonuclease KW Manganese KW Metal-binding XX GO GO:0030145; F:manganese ion binding GO GO:0004523; F:RNA-DNA hybrid ribonuclease activity GO GO:0006401; P:RNA catabolic process GO GO:0005737; C:cytoplasm XX FT From: RNH2_ECOLI (P10442) case FT BINDING 16 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: D FT BINDING 17 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: E FT BINDING 108 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: D end case FT From: RNH2_METJA (Q57599) case FT BINDING 7 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: D FT BINDING 8 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: E FT BINDING 112 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: D end case XX case Size: 181-315; end case case Size: 195-277; end case Related: None; Template: O31744; P10442; O29634; Q57599; O74035; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: in METPP, SYMTH, SYNFM Plasmid: in METPP Comments: Divergent CAUVC not shown in alignment. Possible wrong start in a number of cases. XX # Revision 1.34 2023/06/01 //