AC MF_00053; DC Protein; auto TR HAMAP; MF_00053; -; 1; level=0 XX Names: RNase_HIII XX ID RNH3 DE RecName: Full=Ribonuclease HIII; DE Short=RNase HIII; DE EC=3.1.26.4; GN Name=rnhC; XX CC -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA CC hybrids. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in CC the absence of substrate. May bind a second metal ion after substrate CC binding.; CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the RNase HII family. RnhC subfamily. XX DR PROSITE; PS51975; RNASE_H_2; 1; trigger=yes DR Pfam; PF01351; RNase_HII; 1; trigger=no DR NCBIfam; TIGR00716; RnhC; 1; trigger=no XX KW Cytoplasm KW Hydrolase KW Nuclease KW Endonuclease KW Magnesium KW Metal-binding XX GO GO:0000287; F:magnesium ion binding GO GO:0004523; F:RNA-DNA hybrid ribonuclease activity GO GO:0006401; P:RNA catabolic process GO GO:0005737; C:cytoplasm XX FT From: RNH3_BACSU (P94541) FT BINDING 100 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: D FT BINDING 101 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: E FT BINDING 205 FT /ligand="a divalent metal cation" FT /ligand_id="ChEBI:CHEBI:60240" FT Condition: D XX Size: 257-316; Related: None; Template: P94541; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.29 2023/06/01 //