AC   MF_00057;
DC   Protein; auto
TR   HAMAP; MF_00057; -; 1; level=0
XX
Names: KdsB
XX
ID   KDSB
case <OC:Shewanella>
DE   RecName: Full=8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase;
DE            EC=2.7.7.90;
DE   AltName: Full=CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase;
else
DE   RecName: Full=3-deoxy-manno-octulosonate cytidylyltransferase;
DE            EC=2.7.7.38;
DE   AltName: Full=CMP-2-keto-3-deoxyoctulosonic acid synthase;
DE            Short=CKS;
DE            Short=CMP-KDO synthase;
end case
GN   Name=kdsB;
XX
case <OC:Shewanella>
CC   -!- FUNCTION: Activates KDO8N (a required 8-carbon sugar) for incorporation
CC       into bacterial lipopolysaccharide in the Shewanella genus.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-
CC         amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate;
CC         Xref=Rhea:RHEA:49284, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:87091, ChEBI:CHEBI:91089; EC=2.7.7.90;
else
CC   -!- FUNCTION: Activates KDO (a required 8-carbon sugar) for incorporation
CC       into bacterial lipopolysaccharide in Gram-negative bacteria.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-
CC         beta-D-manno-octulosonate + diphosphate; Xref=Rhea:RHEA:23448,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:85986,
CC         ChEBI:CHEBI:85987; EC=2.7.7.38;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-
CC       octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-
CC       deoxy-D-manno-octulosonate and CTP: step 1/1.
end case
case defined <Property:Membrane> and <Property:Membrane=2>
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the KdsB family.
XX
DR   NCBIfam; TIGR00466; KdsB; 1; trigger=no
XX
KW   Cytoplasm
KW   Lipopolysaccharide biosynthesis
KW   Transferase
KW   Nucleotidyltransferase
XX
case <OC:Shewanella>
GO   GO:0016779; F:nucleotidyltransferase activity
else
GO   GO:0008690; F:3-deoxy-manno-octulosonate cytidylyltransferase activity
GO   GO:0033468; P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
end case
GO   GO:0009103; P:lipopolysaccharide biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 230-310;
Related: None;
Template: P04951; P42216; Q8EEA9;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in ACTP2, BURCM, BURA4, PARPJ, BURL3, HYDCU
Plasmid: None
Comments: kpsU from E.coli (KPSU5_ECOLX) is not a duplicate, but a kdsB from a non-K12
 strain.
 Kdo8N is found in lipopolysaccharides of members of the Shewanella genus. (PubMed:23413030)
XX
# Revision 1.33 2023/06/01
//