AC   MF_00058;
DC   Protein; auto
TR   HAMAP; MF_00058; -; 1; level=0
XX
Names: MTD
XX
ID   MTD
DE   RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase;
DE            Short=MTD;
DE            EC=1.5.98.1;
DE   AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase;
GN   Name=mtd;
XX
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
CC   -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC       methylene-H(4)MPT.
else
CC   -!- FUNCTION: Catalyzes the oxidation of methylene-H(4)MPT to methenyl-
CC       H(4)MPT(+).
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized
CC         coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-
CC         tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n);
CC         Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337,
CC         ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC       tetrahydromethanopterin (coenzyme F420 route): step 1/1.
end case
case <OC:Archaeoglobales>
CC   -!- PATHWAY: Metabolic intermediate metabolism; lactate oxidation.
end case
CC   -!- SIMILARITY: Belongs to the MTD family.
XX
DR   Pfam; PF01993; MTD; 1; trigger=no
XX
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
KW   Methanogenesis
end case
KW   One-carbon metabolism
KW   Oxidoreductase
XX
GO   GO:0030268; F:methylenetetrahydromethanopterin dehydrogenase activity
GO   GO:0006730; P:one-carbon metabolic process
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO   GO:0019386; P:methanogenesis, from carbon dioxide
end case
case <OC:Archaeoglobales>
GO   GO:0019516; P:lactate oxidation
end case
XX
FT   None
XX
Size: 273-283;
Related: None;
Template: P94951; O29544;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.24 2024/04/30
//