AC   MF_00068;
DC   Protein; auto
TR   HAMAP; MF_00068; -; 1; level=0
XX
Names: MurQ
XX
ID   MURQ
DE   RecName: Full=N-acetylmuramic acid 6-phosphate etherase;
DE            Short=MurNAc-6-P etherase;
DE            EC=4.2.1.126;
DE   AltName: Full=N-acetylmuramic acid 6-phosphate hydrolase;
DE   AltName: Full=N-acetylmuramic acid 6-phosphate lyase;
GN   Name=murQ;
XX
case <OC:Pseudomonadota>
CC   -!- FUNCTION: Specifically catalyzes the cleavage of the D-lactyl ether
CC       substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-
CC       lactate. Together with AnmK, is also required for the utilization of
CC       anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the
CC       medium or derived from its own cell wall murein, and thus plays a role
CC       in cell wall recycling.
else
CC   -!- FUNCTION: Specifically catalyzes the cleavage of the D-lactyl ether
CC       substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-
CC       lactate.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-
CC         acetyl-D-glucosamine 6-phosphate; Xref=Rhea:RHEA:26410,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:16004, ChEBI:CHEBI:57513,
CC         ChEBI:CHEBI:58722; EC=4.2.1.126;
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylmuramate degradation.
case <OC:Pseudomonadota>
CC   -!- PATHWAY: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate
CC       degradation.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling.
end case
CC   -!- SUBUNIT: Homodimer.
case <OC:Enterobacterales>
CC   -!- INDUCTION: Induced by MurNAc 6-phosphate that releases the repressor
CC       MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-
CC       phosphate.
end case
CC   -!- MISCELLANEOUS: A lyase-type mechanism (elimination/hydration) is
CC       suggested for the cleavage of the lactyl ether bond of MurNAc 6-
CC       phosphate, with the formation of an alpha,beta-unsaturated aldehyde
CC       intermediate with (E)-stereochemistry, followed by the syn addition of
CC       water to give product.
CC   -!- SIMILARITY: Belongs to the GCKR-like family. MurNAc-6-P etherase
CC       subfamily.
XX
DR   PROSITE; PS01272; GCKR; 1; trigger=no
DR   PROSITE; PS51464; SIS; 1; trigger=yes
DR   Pfam; PF01380; SIS; 1; trigger=no
DR   NCBIfam; TIGR00274; TIGR00274; 1; trigger=no
XX
KW   Carbohydrate metabolism
KW   Lyase
XX
GO   GO:0016835; F:carbon-oxygen lyase activity
GO   GO:0006040; P:amino sugar metabolic process
case <OC:Pseudomonadota>
GO   GO:0009254; P:peptidoglycan turnover
end case
XX
FT   From: MURQ_ECOLI (P76535)
FT   ACT_SITE        83
FT                   /note="Proton donor"
FT   Condition: E
FT   ACT_SITE        114
FT   Condition: E
XX
Size: 274-316;
Related: None;
Template: P76535;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACLD, ENTFA, LACPL, VIBCH, VIBPA
Plasmid: in DEIGD
Comments: None
XX
# Revision 1.37 2023/06/01
//