AC   MF_00075;
DC   Protein; auto
TR   HAMAP; MF_00075; -; 1; level=0
XX
Names: IF_1
XX
case not <OG:Chloroplast>
ID   IF1
DE   RecName: Full=Translation initiation factor IF-1;
end case
case <OG:Chloroplast>
ID   IF1C
DE   RecName: Full=Translation initiation factor IF-1, chloroplastic;
end case
GN   Name=infA;
XX
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit
CC       to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps
CC       modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).
CC       Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are
CC       released leaving the mature 70S translation initiation complex.
CC   -!- SUBUNIT: Component of the 30S ribosomal translation pre-initiation
CC       complex which assembles on the 30S ribosome in the order IF-2 and IF-3,
CC       IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at
CC       any time during PIC assembly.
case not <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
CC   -!- SIMILARITY: Belongs to the IF-1 family.
XX
DR   Pfam; PF01176; eIF-1a; 1; trigger=no
DR   NCBIfam; TIGR00008; InfA; 1; trigger=no
DR   PROSITE; PS50832; S1_IF1_TYPE; 1; trigger=yes
XX
case not <OG:Chloroplast>
KW   Cytoplasm
end case
KW   Initiation factor
KW   Protein biosynthesis
KW   RNA-binding
KW   rRNA-binding
case <OC:Bacillaceae> and <FT:1>
KW   Phosphoprotein
end case
XX
GO   GO:0019843; F:rRNA binding
GO   GO:0003743; F:translation initiation factor activity
GO   GO:0006413; P:translational initiation
GO   GO:0043022; F:ribosome binding
case not <OG:Chloroplast>
GO   GO:0005737; C:cytoplasm
end case
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
XX
FT   From: IF1_BACSU (P20458)
case <OC:Bacillaceae>
FT   MOD_RES         60
FT                   /note="Phosphotyrosine"
FT   Condition: Y
end case
XX
Size: 70-113;
Related: None;
Template: P69222; Q5SHR1;
Scope:
 Bacteria
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in CUPMC, RUEST
Comments: Possible wrong start in MYCSP
 Pseudogene in the plastid genome in most rosids (including ARATH), and
 Solanaceae (including TOBAC).
 MEDLINE=21149877; PubMed=11251102; DOI=10.1105/tpc.13.3.645;
 Millen R.S., Olmstead R.G., Adams K.L., Palmer J.D., Lao N.T.,
 Heggie L., Kavanagh T.A., Hibberd J.M., Gray J.C., Morden C.W.,
 Calie P.J., Jermiin L.S., Wolfe K.H.;
 "Many parallel losses of infA from chloroplast DNA during angiosperm
 evolution with multiple independent transfers to the nucleus.";
 Plant Cell 13:645-658(2001).
XX
# Revision 1.44 2023/06/01
//