AC   MF_00076;
DC   Protein; auto
TR   HAMAP; MF_00076; -; 1; level=0
XX
Names: HisB
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ID   HIS7
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=hisB;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family.
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DR   Pfam; PF00475; IGPD; 1; trigger=no
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1; trigger=no
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1; trigger=no
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KW   Cytoplasm
KW   Amino-acid biosynthesis
KW   Histidine biosynthesis
KW   Lyase
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GO   GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity
GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   None
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Size: 176-216;
Related: MF_01022!;
Template: Q02134;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Longer N-terminal in NEIMA and NEIMB; not shown in alignment and not taken
 into account in size range.
 See MF_01022 for bifunctional hisB.
XX
# Revision 1.33 2019/11/20
//