AC   MF_00077;
DC   Protein; auto
TR   HAMAP; MF_00077; -; 1; level=0
XX
Names: tRNA_methyltr_aTrm56
XX
ID   TRM56
DE   RecName: Full=tRNA (cytidine(56)-2'-O)-methyltransferase;
DE            EC=2.1.1.206;
DE   AltName: Full=tRNA ribose 2'-O-methyltransferase aTrm56;
XX
CC   -!- FUNCTION: Specifically catalyzes the AdoMet-dependent 2'-O-ribose
CC       methylation of cytidine at position 56 in tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-
CC         methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42968, Rhea:RHEA-COMP:10308, Rhea:RHEA-COMP:10309,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.206;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the aTrm56 family.
XX
DR   Pfam; PF01994; Trm56; 1; trigger=no
DR   Pfam; PF01966; HD; 0-1; trigger=no
DR   NCBIfam; TIGR00277; HDIG; 0-1; trigger=no
DR   PROSITE; PS51831; HD; 0-1; trigger=yes
XX
KW   Cytoplasm
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
XX
GO   GO:0008175; F:tRNA methyltransferase activity
GO   GO:0002128; P:tRNA nucleoside ribose methylation
GO   GO:0005737; C:cytoplasm
XX
FT   From: TRM56_PYRHO (O58214)
FT   BINDING         109..113
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: G-[GAS]-[ED]-[KR]-V
FT   BINDING         127..134
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [VI]-[GAS]-N-Q-P-H-S-E
FT   BINDING         80
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: L
XX
Size: 168-218;
Related: None;
Template: O58214; Q9UYD1; O29507;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: <HD domain>
Duplicate: None
Plasmid: None
Comments: Shorter N-terminus in SULAC and SACS2.
XX
# Revision 1.33 2023/06/01
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