AC   MF_00078;
DC   Protein; auto
TR   HAMAP; MF_00078; -; 1; level=0
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Names: PMDh_S
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ID   PMDHS
DE   RecName: Full=Phosphomevalonate dehydratase small subunit;
DE            Short=PMDh small subunit;
DE            Short=PMDh-S;
DE            EC=4.2.1.182;
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CC   -!- FUNCTION: Component of a hydro-lyase that catalyzes the dehydration of
CC       mevalonate 5-phosphate (MVA5P) to form trans-anhydromevalonate 5-
CC       phosphate (tAHMP). Involved in the archaeal mevalonate (MVA) pathway,
CC       which provides fundamental precursors for isoprenoid biosynthesis, such
CC       as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-5-phosphomevalonate = (2E)-3-methyl-5-phosphooxypent-2-
CC         enoate + H2O; Xref=Rhea:RHEA:78975, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:58146, ChEBI:CHEBI:229665; EC=4.2.1.182;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:78976;
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC       via mevalonate pathway.
CC   -!- SUBUNIT: Heterodimer composed of a large subunit (PMDh-L) and a small
CC       subunit (PMDh-S).
CC   -!- SIMILARITY: Belongs to the AcnX type II small subunit family.
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DR   Pfam; PF01989; AcnX_swivel_put; 1; trigger=no
DR   PIRSF; PIRSF004966; UCP004966; 1; trigger=no
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KW   Isoprene biosynthesis
KW   Lyase
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GO   GO:0016836; F:hydro-lyase activity
GO   GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway
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FT   From: PMDHS_AERPE (Q9YA49)
FT   ACT_SITE        58
FT                   /note="Proton acceptor"
FT   Condition: S
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Size: 102-152;
Related: None;
Template: Q9YA49; Q8PWQ2; Q5JGJ7;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Version: 12
# Last updated date: 2024-05-22
# Created date: 2005-02-28
//