AC   MF_00079;
DC   Protein; auto
TR   HAMAP; MF_00079; -; 1; level=0
XX
Names: HisG_Long
XX
ID   HIS1
DE   RecName: Full=ATP phosphoribosyltransferase;
DE            Short=ATP-PRT;
DE            Short=ATP-PRTase;
DE            EC=2.4.2.17;
GN   Name=hisG;
XX
CC   -!- FUNCTION: Catalyzes the condensation of ATP and 5-phosphoribose 1-
CC       diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial
CC       role in the pathway because the rate of histidine biosynthesis seems to
CC       be controlled primarily by regulation of HisG enzymatic activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-
CC         alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017,
CC         ChEBI:CHEBI:73183; EC=2.4.2.17;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- ACTIVITY REGULATION: Feedback inhibited by histidine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Enterobacterales> or <OC:Mycobacteriaceae>
CC   -!- SUBUNIT: Equilibrium between an active dimeric form, an inactive
CC       hexameric form and higher aggregates. Interconversion between the
CC       various forms is largely reversible and is influenced by the natural
CC       substrates and inhibitors of the enzyme.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ATP phosphoribosyltransferase family. Long
CC       subfamily.
XX
DR   Pfam; PF01634; HisG; 1; trigger=no
DR   NCBIfam; TIGR00070; HisG; 1; trigger=no
DR   NCBIfam; TIGR03455; HisG_C-term; 1; trigger=no
DR   PROSITE; PS01316; ATP_P_PHORIBOSYLTR; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   ATP-binding
KW   Cytoplasm
KW   Glycosyltransferase
KW   Histidine biosynthesis
KW   Magnesium
KW   Metal-binding
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0003879; F:ATP phosphoribosyltransferase activity
GO   GO:0000287; F:magnesium ion binding
GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 281-325;
Related: MF_01018;
Template: P60757; P00499; P9WMN1;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Possible wrong start in HAEIN.
 Possible wrong start in ARCFU; not shown in alignment and not taken into
 account in size range.
 See MF_01018 for the entry relevant to the "short" hisG.
XX
# Revision 1.43 2023/06/01
//