AC   MF_00090;
DC   Protein; auto
TR   HAMAP; MF_00090; -; 1; level=0
XX
Names: PIMT
XX
ID   PIMT
DE   RecName: Full=Protein-L-isoaspartate O-methyltransferase;
DE            EC=2.1.1.77;
DE   AltName: Full=L-isoaspartyl protein carboxyl methyltransferase;
DE   AltName: Full=Protein L-isoaspartyl methyltransferase;
DE   AltName: Full=Protein-beta-aspartate methyltransferase;
DE            Short=PIMT;
GN   Name=pcm;
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CC   -!- FUNCTION: Catalyzes the methyl esterification of L-isoaspartyl residues
CC       in peptides and proteins that result from spontaneous decomposition of
CC       normal L-aspartyl and L-asparaginyl residues. It plays a role in the
CC       repair and/or degradation of damaged proteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-L-isoaspartate + S-adenosyl-L-methionine =
CC         [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:12705, Rhea:RHEA-COMP:12143, Rhea:RHEA-
CC         COMP:12144, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90596,
CC         ChEBI:CHEBI:90598; EC=2.1.1.77;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC       isoaspartyl/D-aspartyl protein methyltransferase family.
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DR   Pfam; PF01135; PCMT; 1; trigger=no
DR   NCBIfam; TIGR00080; Pimt; 1; trigger=no
DR   PROSITE; PS01279; PCMT; 1; trigger=no
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KW   Cytoplasm
KW   Transferase
KW   Methyltransferase
KW   S-adenosyl-L-methionine
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GO   GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO   GO:0036211; P:protein modification process
GO   GO:0030091; P:protein repair
GO   GO:0005737; C:cytoplasm
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FT   From: PIMT_ECOLI (P0A7A5)
FT   ACT_SITE        59
FT   Condition: S
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Size: 198-327;
Related: None;
Template: Q56308; Q8TZR3;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: <Unknown>
Duplicate: in ANADF, ARCFU, GEOUR, MARN8, NITOC, NITMU, PELPD, POLSJ, CUPNH,
 RHOP2, SHESH, SYNFM
Plasmid: None
Comments: Possible wrong starts. Unknown C-terminal domain in THEMA.
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# Revision 1.32 2023/06/01
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