AC MF_00091; DC Protein; auto TR HAMAP; MF_00091; -; 1; level=0 XX Names: LuxS XX ID LUXS DE RecName: Full=S-ribosylhomocysteine lyase; DE EC=4.4.1.21; DE AltName: Full=AI-2 synthesis protein; DE AltName: Full=Autoinducer-2 production protein LuxS; GN Name=luxS; XX CC -!- FUNCTION: Involved in the synthesis of autoinducer 2 (AI-2) which is CC secreted by bacteria and is used to communicate both the cell density CC and the metabolic potential of the environment. The regulation of gene CC expression in response to changes in cell density is called quorum CC sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to CC homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). CC -!- CATALYTIC ACTIVITY: CC Reaction=S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5- CC dihydroxypentane-2,3-dione + L-homocysteine; Xref=Rhea:RHEA:17753, CC ChEBI:CHEBI:29484, ChEBI:CHEBI:58195, ChEBI:CHEBI:58199; EC=4.4.1.21; case CC -!- COFACTOR: CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; CC Note=Binds 1 Fe cation per subunit.; end case CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the LuxS family. XX DR Pfam; PF02664; LuxS; 1; trigger=no DR PRINTS; PR01487; LUXSPROTEIN; 1; trigger=no XX KW Quorum sensing KW Autoinducer synthesis KW Lyase case KW Iron KW Metal-binding end case XX GO GO:0043768; F:S-ribosylhomocysteine lyase activity GO GO:0009372; P:quorum sensing XX FT From: LUXS_BACSU (O34667) FT BINDING 54 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Condition: H FT BINDING 58 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Condition: H FT BINDING 126 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Condition: C XX Size: 151-173; Related: None; Template: O34667; Q9PN97; Q9RRU8; P45578; P44007; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.28 2022/11/19 //