AC   MF_00094;
DC   Protein; auto
TR   HAMAP; MF_00094; -; 1; level=0
XX
Names: Rel_fac_2
XX
ID   RF2
DE   RecName: Full=Peptide chain release factor 2;
DE            Short=RF-2;
GN   Name=prfB;
XX
CC   -!- FUNCTION: Peptide chain release factor 2 directs the termination of
CC       translation in response to the peptide chain termination codons UGA and
CC       UAA.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
case <FT:1>
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF2.
end case
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family.
XX
DR   Pfam; PF00472; RF-1; 1; trigger=no
DR   NCBIfam; TIGR00020; PrfB; 1; trigger=no
DR   PROSITE; PS00745; RF_PROK_I; 1; trigger=no
XX
KW   Cytoplasm
KW   Protein biosynthesis
case <FT:1>
KW   Methylation
end case
XX
GO   GO:0016149; F:translation release factor activity, codon specific
GO   GO:0006415; P:translational termination
GO   GO:0005737; C:cytoplasm
XX
FT   From: RF2_ECOLI (P07012)
FT   MOD_RES         252
FT                   /note="N5-methylglutamine"
FT   Condition: Q
XX
Size: 359-377;
Related: MF_00093;
Template: P07012;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: In about 70% of bacterial genomes the mRNA encoding RF-2 has 2
 partially overlapping reading frames. Synthesis of full-length RF-2
 requires +1 frameshifting at the end of the first open reading frame,
 usually on a UGA codon. This frameshifting serves an autoregulatory
 function; when RF-2 levels are low frameshifting occurs and full-length
 protein is produced.
XX
# Revision 1.21 2023/06/01
//