AC MF_00100; DC Protein; auto c? or TR HAMAP; MF_00100_B; -; 1; level=0 c? TR HAMAP; MF_00100_A; -; 1; level=0 XX Names: IF_2 XX case ID IF2 DE RecName: Full=Translation initiation factor IF-2; end case case ID IF2C DE RecName: Full=Translation initiation factor IF-2, chloroplastic; end case case ID IF2P DE RecName: Full=Probable translation initiation factor IF-2; end case GN Name=infB; XX case CC -!- FUNCTION: One of the essential components for the initiation of protein CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis CC and promotes its binding to the 30S ribosomal subunits. Also involved CC in the hydrolysis of GTP during the formation of the 70S ribosomal CC complex. CC -!- SUBCELLULAR LOCATION: Cytoplasm. end case case CC -!- FUNCTION: Function in general translation initiation by promoting the CC binding of the formylmethionine-tRNA to ribosomes. Seems to function CC along with eIF-2. end case case CC -!- FUNCTION: One of the essential components for the initiation of protein CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis CC and promotes its binding to the 30S ribosomal subunits. Also involved CC in the hydrolysis of GTP during the formation of the 70S ribosomal CC complex. CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast. end case CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase CC superfamily. Classic translation factor GTPase family. IF-2 subfamily. XX DR Pfam; PF00009; GTP_EFTU; 1; trigger=no DR NCBIfam; TIGR00487; IF-2; 1; trigger=no DR NCBIfam; TIGR00491; AIF-2; 1; trigger=no DR PROSITE; PS51722; G_TR_2; 1; trigger=no DR PROSITE; PS01176; IF2; 1; trigger=no XX case KW Cytoplasm end case KW Initiation factor KW Protein biosynthesis KW GTP-binding KW Nucleotide-binding XX GO GO:0003924; F:GTPase activity GO GO:0003743; F:translation initiation factor activity GO GO:0006413; P:translational initiation case GO GO:0005737; C:cytoplasm end case case GO GO:0009507; C:chloroplast end case XX FT From: IF2_ECOLI (P0A705) case or FT BINDING 398..405 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT Condition: G-H-V-D-H-G-K-T FT BINDING 444..448 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT Condition: D-T-P-G-H FT BINDING 498..501 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT Condition: [NST]-K-[LIVCMT]-D FT REGION 392..540 FT /note="G-domain" end case FT From: IF2P_METTH (O26359) case FT BINDING 12..19 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT Condition: G-H-V-D-[HVA]-G-K-T FT BINDING 76..80 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT Condition: D-T-P-G-H FT BINDING 130..133 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT Condition: [NT]-K-[LIV]-D end case XX case Size: 571-1183; end case case Size: 589-620; end case Related: None; Template: P04766; P0A705; P48515; Q9HNQ2; O26359; Scope: Bacteria Archaea Plastid Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: Intein in some members. XX # Revision 1.53 2023/06/01 //