AC   MF_00104;
DC   Protein; auto
TR   HAMAP; MF_00104; -; 1; level=0
XX
Names: RNase_III
XX
ID   RNC
DE   RecName: Full=Ribonuclease 3;
DE            EC=3.1.26.3;
DE   AltName: Full=Ribonuclease III;
DE            Short=RNase III;
GN   Name=rnc;
XX
CC   -!- FUNCTION: Digests double-stranded RNA. Involved in the processing of
CC       primary rRNA transcript to yield the immediate precursors to the large
CC       and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when
CC       they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA
CC       of type II CRISPR loci if present in the organism.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
XX
DR   Pfam; PF00035; dsrm; 1; trigger=no
DR   Pfam; PF00636; Ribonuclease_3; 1; trigger=no
DR   NCBIfam; TIGR02191; RNaseIII; 1; trigger=no
DR   PROSITE; PS50137; DS_RBD; 1; trigger=yes
DR   PROSITE; PS00517; RNASE_3_1; 1; trigger=no
DR   PROSITE; PS50142; RNASE_3_2; 1; trigger=yes
XX
KW   Cytoplasm
KW   Hydrolase
KW   Nuclease
KW   Endonuclease
case <FT:3> or <FT:4> or <FT:5>
KW   Magnesium
KW   Metal-binding
end case
case <Feature:PS50137>
KW   RNA-binding
KW   rRNA-binding
end case
KW   mRNA processing
KW   rRNA processing
KW   tRNA processing
XX
GO   GO:0004525; F:ribonuclease III activity
GO   GO:0006397; P:mRNA processing
GO   GO:0006364; P:rRNA processing
GO   GO:0005737; C:cytoplasm
XX
FT   From: RNC_AQUAE (O67082)
FT   ACT_SITE        44
FT   Condition: D
FT   ACT_SITE        110
FT   Condition: E
FT   BINDING         40
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: E
FT   BINDING         107
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: [DENS]
FT   BINDING         110
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: E
XX
Size: 221-369;
Related: None;
Template: O67082; P51833; P0A7Y0; Q52698; Q56056; Q9ZBQ7; Q9X0I6;
Scope:
 Bacteria
Fusion:
 Nter: <Unknown>
 Cter: None
Duplicate: in NOSS1, SYNY3
Plasmid: None
Comments: Often predicted too short. Some Mycoplasmas lack the DRBM domain.
 Mycoplasma gallisepticum strains have an unknown N-terminal extension of
 about 400 aa. ROSHA and TRES6 are slightly longer in the middle; ROSHA has
 2 DRBM domains.
XX
# Revision 1.34 2023/06/01
//