AC   MF_00110;
DC   Protein; auto
TR   HAMAP; MF_00110; -; 1; level=0
XX
Names: DHQ_synthase
XX
ID   AROB
DE   RecName: Full=3-dehydroquinate synthase;
DE            Short=DHQS;
DE            EC=4.2.3.4;
GN   Name=aroB;
XX
CC   -!- FUNCTION: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate
CC       7-phosphate (DAHP) to dehydroquinate (DHQ).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-
CC         dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 divalent metal cation per subunit. Can use either Co(2+)
CC       or Zn(2+)
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       2/7.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the sugar phosphate cyclases superfamily.
CC       Dehydroquinate synthase family.
XX
DR   Pfam; PF01761; DHQ_synthase; 1; trigger=no
DR   NCBIfam; TIGR01357; aroB; 1; trigger=no
DR   PIRSF; PIRSF001455; DHQ_synth; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Aromatic amino acid biosynthesis
KW   Cobalt
KW   Cytoplasm
KW   Lyase
KW   Metal-binding
KW   NAD
KW   Nucleotide-binding
KW   Zinc
XX
GO   GO:0003856; F:3-dehydroquinate synthase activity
GO   GO:0009073; P:aromatic amino acid family biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: AROB_MYCTU (P9WPX9)
FT   BINDING         73..78
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [DES]-[GA]-E-x-x-K
FT   BINDING         107..111
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: G-[AV]-x-x-D
FT   BINDING         131..132
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: T-[TS]
FT   BINDING         171..174
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [CFT]-x-x-T
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: E
FT   BINDING         249
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         144
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: K
FT   BINDING         153
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: K
XX
Size: 331-394;
Related: MF_03143!;
Template: P07639; Q6GGU4; P9WPX9; P56081;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_00109 (aroK)
 Cter: <gppA / PPX>
Duplicate: None
Plasmid: None
Comments: Possible wrong start in CHLPN
XX
# Revision 1.45 2023/06/01
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