AC   MF_00111;
DC   Protein; auto
TR   HAMAP; MF_00111; -; 1; level=0
XX
Names: MurA
XX
ID   MURA
DE   RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase;
DE            EC=2.5.1.7;
DE   AltName: Full=Enoylpyruvate transferase;
DE   AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase;
DE            Short=EPT;
GN   Name=murA;
XX
CC   -!- FUNCTION: Cell wall formation. Adds enolpyruvyl to UDP-N-
CC       acetylglucosamine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine =
CC         phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine;
CC         Xref=Rhea:RHEA:18681, ChEBI:CHEBI:43474, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:58702, ChEBI:CHEBI:68483; EC=2.5.1.7;
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the EPSP synthase family. MurA subfamily.
XX
DR   Pfam; PF00275; EPSP_synthase; 1; trigger=no
DR   NCBIfam; TIGR01072; MurA; 1; trigger=no
XX
KW   Cell cycle
KW   Cell division
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Cytoplasm
KW   Peptidoglycan synthesis
case <FTTag:pyruvyl>
KW   Pyruvate
end case
KW   Transferase
XX
GO   GO:0008760; F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: MURA_ECOLI (P0A749)
FT   BINDING         22..23
FT                   /ligand="phosphoenolpyruvate"
FT                   /ligand_id="ChEBI:CHEBI:58702"
FT   Optional; Condition: K-N
FT   BINDING         120..124
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: R-P-[VILM]-[DE]-[LQ]
FT   BINDING         160..163
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: K-V-S-V
FT   ACT_SITE        115
FT                   /note="Proton donor"
FT   Condition: [CD]
FT   BINDING         91
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: R
FT   BINDING         305
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: D
FT   BINDING         327
FT                   /ligand="UDP-N-acetyl-alpha-D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:57705"
FT   Optional; Condition: [VILM]
FT   MOD_RES         115
FT                   /note="2-(S-cysteinyl)pyruvic acid O-phosphothioketal"
FT   Tag: pyruvyl; Optional; Condition: C
XX
Size: 350-535;
Related: None;
Template: P0A749; P33038;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN, BACC1, BACCR, BACCZ, HALH5, BACHK, BACLD, SHOC1, BACSU,
 CARHZ, CLOAB, CLOPE, CLOTE, ENTFA, GEOKA, LACLA, LACLP, LATSS, LEGPL, LISIN,
 LISMO, OCEIH, PROMA, RHILO, STAAB, STAHJ, STAS1, STRA1, STRA3, STRA5, STRMU,
 STRPM, STRPN, STRP1, STRT1, STRT2, SYMTH, CALS4
Plasmid: in RUEPO
Comments: Longer C-terminus in one copy in LEGPL; not included in size range
XX
# Revision 1.55 2023/11/28
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