AC   MF_00113;
DC   Protein; auto
TR   HAMAP; MF_00113; -; 1; level=0
XX
Names: QueA
XX
ID   QUEA
DE   RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase;
DE            EC=2.4.99.17;
DE   AltName: Full=Queuosine biosynthesis protein QueA;
GN   Name=queA;
XX
CC   -!- FUNCTION: Transfers and isomerizes the ribose moiety from AdoMet to the
CC       7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give
CC       epoxyqueuosine (oQ-tRNA).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-
CC         methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-
CC         methionine; Xref=Rhea:RHEA:32155, Rhea:RHEA-COMP:10342, Rhea:RHEA-
CC         COMP:18582, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708, ChEBI:CHEBI:57844,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:82833, ChEBI:CHEBI:194443;
CC         EC=2.4.99.17;
CC   -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the QueA family.
XX
DR   Pfam; PF02547; Queuosine_synth; 1; trigger=no
DR   NCBIfam; TIGR00113; QueA; 1; trigger=no
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KW   Cytoplasm
KW   Queuosine biosynthesis
KW   S-adenosyl-L-methionine
KW   Transferase
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GO   GO:0016853; F:isomerase activity
GO   GO:0016740; F:transferase activity
GO   GO:0008616; P:queuosine biosynthetic process
GO   GO:0006400; P:tRNA modification
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 334-408;
Related: None;
Template: P0A7F9; A8AYK5;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: RPE-type insertion in RICCN and RICPR.
 Probable wrong start in NOSS1 and DEIRA.
XX
# Revision 1.31 2024/01/31
//