AC   MF_00116;
DC   Protein; auto
TR   HAMAP; MF_00116; -; 1; level=0
XX
Names: dUTPase_bact
XX
ID   DUT
DE   RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
DE            Short=dUTPase;
DE            EC=3.6.1.23;
DE   AltName: Full=dUTP pyrophosphatase;
GN   Name=dut;
XX
CC   -!- FUNCTION: This enzyme is involved in nucleotide metabolism: it produces
CC       dUMP, the immediate precursor of thymidine nucleotides and it decreases
CC       the intracellular concentration of dUTP so that uracil cannot be
CC       incorporated into DNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP
CC       route): step 2/2.
case <OC:Escherichia> or <OC:Mycobacterium>
CC   -!- SUBUNIT: Homotrimer.
end case
CC   -!- SIMILARITY: Belongs to the dUTPase family.
XX
DR   Pfam; PF00692; dUTPase; 1; trigger=no
DR   NCBIfam; TIGR00576; Dut; 1; trigger=no
XX
KW   Hydrolase
KW   Magnesium
KW   Metal-binding
KW   Nucleotide metabolism
XX
GO   GO:0004170; F:dUTP diphosphatase activity
GO   GO:0000287; F:magnesium ion binding
GO   GO:0006226; P:dUMP biosynthetic process
XX
FT   From: DUT_ECOLI (P06968)
FT   BINDING         71..73
FT                   /ligand="substrate"
FT   Optional; Condition: R-S-[GS]
FT   BINDING         88..90
FT                   /ligand="substrate"
FT   Optional; Condition: [TVL]-[IV]-D
FT   BINDING         84
FT                   /ligand="substrate"
FT   Optional; Condition: [NQ]
case not <FT:2>
FT   BINDING         90
FT                   /ligand="substrate"
FT   Optional; Condition: D
end case
FT   BINDING         96
FT                   /ligand="substrate"
FT   Optional; Condition: [KM]
XX
Size: 139-185;
Related: None;
Template: P06968; P9WNS5;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.33 2024/01/25
//