AC   MF_00124;
DC   Protein; auto
TR   HAMAP; MF_00124; -; 1; level=0
XX
Names: Thymidine_kinase
XX
ID   KITH
DE   RecName: Full=Thymidine kinase;
DE            EC=2.7.1.21;
GN   Name=tdk;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
XX
DR   Pfam; PF00265; TK; 1; trigger=no
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1; trigger=no
XX
KW   Cytoplasm
KW   Transferase
KW   Kinase
KW   DNA synthesis
KW   ATP-binding
KW   Nucleotide-binding
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0005524; F:ATP binding
GO   GO:0004797; F:thymidine kinase activity
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0006259; P:DNA metabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: KITH_CLOAB (Q97F65)
FT   BINDING         15..22
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [GSA]-x(4)-G-K-[ST]
FT   BINDING         88..91
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [DE]-E-x-[QHN]
FT   ACT_SITE        89
FT                   /note="Proton acceptor"
FT   Condition: E
FT   BINDING         145
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
FT   BINDING         148
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
FT   BINDING         183
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: [CH]
XX
Size: 184-227;
Related: None;
Template: Q97F65; Q9PPP5; P23331; Q81JX0; Q814U0; Q9WYN2;
Scope:
 Archaea
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: There is a divergent tdk in a Bacillus natto plasmid (O52951)
XX
# Revision 1.24 2022/11/19
//