AC   MF_00125;
DC   Protein; auto
TR   HAMAP; MF_00125; -; 1; level=0
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Names: HisZ
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ID   HISZ
DE   RecName: Full=ATP phosphoribosyltransferase regulatory subunit;
GN   Name=hisZ;
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CC   -!- FUNCTION: Required for the first step of histidine biosynthesis. May
CC       allow the feedback regulation of ATP phosphoribosyltransferase activity
CC       by histidine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: This function is generally fulfilled by the C-terminal
CC       part of HisG, which is missing in some bacteria such as this one.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       HisZ subfamily.
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DR   Pfam; PF00587; tRNA-synt_2b; 1; trigger=no
DR   NCBIfam; TIGR00443; HisZ_biosyn_reg; 1; trigger=no
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 0-1; trigger=no
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KW   Cytoplasm
KW   Amino-acid biosynthesis
KW   Histidine biosynthesis
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GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   None
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Size: 270-438;
Related: MF_00127!;
Template: Q02147;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Difficulty to distinguish between hisS and hisZ families.
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# Revision 1.33 2023/06/01
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