AC   MF_00132;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_00132; -; 1; level=0
XX
Names: Top6A
XX
ID   TOP6A
DE   RecName: Full=Type 2 DNA topoisomerase 6 subunit A;
DE            EC=5.6.2.2;
DE   AltName: Full=Type II DNA topoisomerase VI subunit A;
GN   Name=top6A;
XX
CC   -!- FUNCTION: Relaxes both positive and negative superturns and exhibits a
CC       strong decatenase activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBUNIT: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
CC   -!- SIMILARITY: Belongs to the TOP6A family.
XX
DR   Pfam; PF04406; TP6A_N; 1; trigger=no
DR   PRINTS; PR01550; TOP6AFAMILY; 1; trigger=no
DR   PRINTS; PR01552; TPISMRASE6A; 1; trigger=no
DR   PROSITE; PS52041; TOPO_IIB; 1; trigger=yes
XX
KW   ATP-binding
KW   DNA-binding
KW   Isomerase
KW   Magnesium
KW   Metal-binding
KW   Nucleotide-binding
KW   Topoisomerase
XX
GO   GO:0003677; F:DNA binding
GO   GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO   GO:0000287; F:magnesium ion binding
GO   GO:0006265; P:DNA topological change
GO   GO:0006268; P:DNA unwinding involved in DNA replication
XX
FT   From: TOP6A_METJA (Q57815)
FT   ACT_SITE        103
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT   Condition: Y
FT   BINDING         197
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: E
FT   BINDING         249
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
XX
Size: 340-453;
Related: None;
Template: Q57815; Q8PUB7; O05208;
Scope:
 Archaea
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.37 2023/10/17
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