AC   MF_00134;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_00134_B; -; 1; level=0
c?   <OC:Archaea>
TR   HAMAP; MF_00134_A; -; 1; level=0
XX
Names: IGPS
XX
ID   TRPC
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family.
XX
DR   Pfam; PF00218; IGPS; 1; trigger=no
DR   PROSITE; PS00614; IGPS; 1; trigger=no
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KW   Amino-acid biosynthesis
KW   Aromatic amino acid biosynthesis
KW   Tryptophan biosynthesis
KW   Lyase
KW   Decarboxylase
XX
GO   GO:0004425; F:indole-3-glycerol-phosphate synthase activity
GO   GO:0000162; P:tryptophan biosynthetic process
XX
FT   None
XX
case <OC:Bacteria>
Size: 250-305;
end case
case <OC:Archaea>
Size: 226-274;
end case
Related: None;
Template: Q56319; P00909; Q06121;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: MF_00135 (trpF); MF_00211 (trpD)
Duplicate: in NOSS1, TRIV2, PSEU2, STRCO
Plasmid: None
Comments: Possible wrong start in THEKO, SYNY3 and VIBPA
XX
# Revision 1.33 2019/11/18
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