AC   MF_00136;
DC   Protein; auto
TR   HAMAP; MF_00136; -; 1; level=0
XX
Names: S_AdoMet_synth2
XX
case <OC:Archaea>
ID   METK
DE   RecName: Full=S-adenosylmethionine synthase;
DE            Short=AdoMet synthase;
DE            EC=2.5.1.6;
DE   AltName: Full=Methionine adenosyltransferase;
end case
case <OC:Bacteria>
ID   METL
DE   RecName: Full=Probable S-adenosylmethionine synthase;
DE            Short=AdoMet synthase;
DE            EC=2.5.1.6;
DE   AltName: Full=Methionine adenosyltransferase;
end case
GN   Name=mat;
XX
CC   -!- FUNCTION: Catalyzes the formation of S-adenosylmethionine from
CC       methionine and ATP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + L-methionine = diphosphate + phosphate + S-
CC         adenosyl-L-methionine; Xref=Rhea:RHEA:21080, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:59789; EC=2.5.1.6;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis;
CC       S-adenosyl-L-methionine from L-methionine: step 1/1.
CC   -!- SIMILARITY: Belongs to the AdoMet synthase 2 family.
XX
DR   Pfam; PF01941; AdoMet_Synthase; 1; trigger=no
XX
KW   Transferase
KW   One-carbon metabolism
KW   ATP-binding
KW   Nucleotide-binding
KW   Magnesium
XX
GO   GO:0005524; F:ATP binding
GO   GO:0000287; F:magnesium ion binding
GO   GO:0004478; F:methionine adenosyltransferase activity
GO   GO:0006730; P:one-carbon metabolic process
XX
FT   From: METK_METJA (Q58605)
FT   BINDING         141..146
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [GK]-x-G-S-x-D
XX
Size: 397-410;
Related: None;
Template: Q58605;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: AQUAE seems to have 2 copies of S-adenosylmethionine synthase, one (O67222) belonging to the
 S-adenosylmethionine synthase type 1 family (MF_00086) and the other (O67275) matching the type 2 family (this HAMAP rule).
XX
# Revision 1.32 2022/11/19
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