AC   MF_00137;
DC   Protein; auto
TR   HAMAP; MF_00137; -; 1; level=0
XX
Names: SAICAR_synth
XX
ID   PUR7
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase;
GN   Name=purC;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP +
CC         L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-
CC         4-carboxamido]succinate + ADP + 2 H(+) + phosphate;
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
XX
DR   Pfam; PF01259; SAICAR_synt; 1; trigger=no
DR   NCBIfam; TIGR00081; purC; 1; trigger=no
DR   NCBIfam; TIGR02735; purC_vibrio; 0-1; trigger=no
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1; trigger=no
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1; trigger=no
XX
KW   ATP-binding
KW   Ligase
KW   Nucleotide-binding
KW   Purine biosynthesis
XX
GO   GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO   GO:0006189; P:'de novo' IMP biosynthetic process
XX
FT   None
XX
Size: 216-367;
Related: None;
Template: P0A7D7;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in AGRFC, BRADU, CAUVC, RHILO
Plasmid: None
Comments: Highly divergent ARCFU and HALSA; sequences not included in alignment.
 Seems to be absent in AERPE.
 Some of the Alphaproteobacteria have a possible second copy.
XX
# Revision 1.39 2023/06/01
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